OBJECTIVE To estimate the population pharmacokinetic parameters of tobramycin by iterative two stage method. METHOD The clinical data(n=154) were collected from 56 patients with respiratory tract infection receiving tobramycin by intramuscular injection.The concentrations of tobramycin in serum were determined by fluorescence polarization immunoassay.The population pharmacokinetic parameters were estimated by iterative two stage method. The influence of sex, age, body weight and creatinine clearance on pharmacokinetics was investigated. RESULTS The population pharmacokinetic parameters in 56 patients were CL(75.65±16.88) mL·h-1·kg-1，Vd (0.2613±0.0438) L·kg-1and t1/2(2.46±0.51) h respectively.The pharmacokinetic parameters of tobramycin were shown to be influenced by age, body weight and creatinine clearance. CONCLUSION Iterative two stage method is suitable for estimating population pharmacokinetic parameters,optimizing individualizing dosage regimens and forecasting plasma concentration of medications.
Key words
tobramycin /
population pharmacokinetics
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References
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