［1］Perucca E.A pharmacological and clinical review of topiramate,a new antiepileptic drug［J］.Pharmacol Res,1997,35(4):241. ［2］Britton JW,So EL.New antiepileptic drugs:prospects for the future［J］.J Epilepsy,1995,8:267. ［3］Privitera MD.Topiramate:a new antiepileptic drug［J］.Ann Pharma-cother,1997,31(10):1164. ［4］Doose DR,Walker SA,Gisclon LG,et al.Single-dose pharmacokineics and effect of food on the bioavailability of topiramate,a novel antiepi-lepticdrug［J］.J Clin Pharmacol,1996,36:884. ［5］Perucca E,Bialer M.The clinical pharmacokinetics of the mewer an-tiepileptic drug:focus on topiramate,zonisamide and tiagabine［J］.Clin Pharmacokinet,1996,31:29. ［6］Shorvon SD.Safety to topiramate:adverse events and relationships to dosing［J］.Epilepsia,1996,37(Suppl 2):s18. ［7］Bourgeois BF.Drug interaction profile of topiramate［J］.Epilepsia,1996,37(Suppl 2):s14. ［8］Tartara A,Sartori I,Manni R,et al.Efficacy and safety of topiramate in refratory epilepsy:a longterm prospective trial［J］.Ital J Neurol Sci,1996,17:429. ［9］Markind JE.Topiramate:a new antiepileptic drug［J］.Am J Health Syst Pharm,1998,55(6):554.