OBJECTIVE:The pharmacokinetics of Duxil (almitrine/raubasine) were studied in ten healthy volunteers after a single oral dose. METHODS:The plasma concentrations of almitrine and raubasine were determined by means of highperformance liquid chromatography. RESULTS:The concentrationtime curves of almitrine and raubasine were fitted to a 2compartment model.The pharmacokinetic parameters of almitrine and raubasine were calculated as following:almitrine:AUC(34174.91±2335.17) μg·h·L-1,tmax(3.81±0.76) h,cmax(816.76±70.07) μg·L-1;raubasine:AUC(1116.15±81.85) μg·h·L-1,tmax(1.27±0.22) h,cmax(374.04±71.71) μg·L-1. CONCLUSION:This study provides the pharmacokintic parameters for clinical and is benefical to rational use of duxil.