Pharmacokinetics of Duxil in healthy volunteers

Liu Lei

Chinese Pharmaceutical Journal ›› 2000, Vol. 35 ›› Issue (05) : 326-329.

Chinese Pharmaceutical Journal ›› 2000, Vol. 35 ›› Issue (05) : 326-329.
临床药学

Pharmacokinetics of Duxil in healthy volunteers

  • Liu Lei
Author information +
History +

Abstract

OBJECTIVE:The pharmacokinetics of Duxil (almitrine/raubasine) were studied in ten healthy volunteers after a single oral dose. METHODS:The plasma concentrations of almitrine and raubasine were determined by means of highperformance liquid chromatography. RESULTS:The concentrationtime curves of almitrine and raubasine were fitted to a 2compartment model.The pharmacokinetic parameters of almitrine and raubasine were calculated as following:almitrine:AUC(34174.91±2335.17) μg·h·L-1,tmax(3.81±0.76) h,cmax(816.76±70.07) μg·L-1;raubasine:AUC(1116.15±81.85) μg·h·L-1,tmax(1.27±0.22) h,cmax(374.04±71.71) μg·L-1. CONCLUSION:This study provides the pharmacokintic parameters for clinical and is benefical to rational use of duxil.

Key words

almitrine / raubasine / Duxil / pharmacokintics

Cite this article

Download Citations
Liu Lei . Pharmacokinetics of Duxil in healthy volunteers[J]. Chinese Pharmaceutical Journal, 2000, 35(05): 326-329

References

[1]陈新谦,金有豫主偏.新编药物学.第14版.北京:人民卫生出版社,1997:580. [2]王雪琴,郭华,王维思.HPLC法测定进口片的含量.药物分析杂志,1997,17(2):126. [3]Stavchansky S,Doluisio JT,Macleod CM,et al.Relative bioavailability of almitrine bisemesylate in humans.Biopharm Drug Dispos,1989,10(3):239. [4]法国OPV-维德出版社编.维德临床用药年鉴(1998年版).北京:中信出版社,1998:251.

28

Accesses

0

Citation

Detail

Sections
Recommended

/