OBJECTIVE: To study the preparation of isoniazid encapsulated niosome (INH-NS) and evaluate its quality. METHODS: The niosomes were prepared by hand shaking method.The morphology of INHNS,the entrapment efficiency and the stability of INH-NS were studies. RESULTS: The niosomes were spherical with the diameter over 2.21～6.78 μm and the extent of entrpment of the INHNS was 24.95%.The INH-NS was stable for three months when stored in refrigerator or at room temperature. CONCLUSION: The entrapment efficiency of INHNS and the stability of INHNS prepared by handshaking method was good.
Key words
isoniazid /
niosome /
uniform design method
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Footnotes
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