OBJECTIVE:To evaluate the efficacy and safety of cefoperazone/sulbactam in the treatment of bacterial infections.METHODS:60 patients with infection were enrolled in a randomized controlled open clinical trial.RESULTS:In the randomized controlled group,the overall clinical efficacy rates of cefoperazone/sulbactam and cefotaxime were 95.51% and 90.5% respectively,the bacteriological response were 95.23% and 90.0% respectively,the rates of adverse drug reaction were 9.09% and 9.52% respectively.There was no significant difference between the two groups.In the open group,the clinical efficacy rate,the bacteriological eradication and the rate of adverse drug reaction of cefoperazone/sulbactam was 95.33%,87,5% and 12.0% respectively. The susceptibility rates of the bacteria isolated to cefoperazone/sulbactam and cefotaxime were similar.CONCLUSIONS:cefoperazone/sulbactam is highly effective and well tolerated.
Key words
cefoperazone/sulbactam /
cefotaxime /
randomized controlled /
clinical trial
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Footnotes
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