OBJECTIVE:To study on method of inhalation simulation test in vitro.The effective dose of inhalation was deter mined.METHOD:The imitated twin-stage liq wuid impinger was used to dtermine the effective dose of inhalation.There was 7ml receiving liquid in stageⅠ,and 30 ml in stageⅡ (simulated action position).The aspirated speed was 60L·min-1.The test results were compared with that reported.RESULTS:There sults were corresponded with the foreign reports.The effective dose of inhalation was related to the dosage form,active ingredient properties and the receiving liquid kings.CONCLUSION:The imitated twin-stage liquid impinger could be used to control the quality of inhalation product.
Key words
inhalation /
the effective dose /
twin-stage liquid impinger
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References
1 Hallworth GW.The twin impinger:a simple device for assessing the delivery of drtlgs from meterde dose pressurized aerosol inhalers.J Pharmacol,1987,39:966.
2 Martin GP,Bell AE,Marriott C.An in vitro method for assessing particle deposition from metered pressurised aerosols and dry powder inhalers.Int J Pharm,1988,44(1):57.
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Footnotes
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