OBJECTIVE:To study the effect sof flavone mononers(Z-1,Z-2)separated from Erigeron bonariensis on fibrosis.METHODS:Crystal violets taining method and 3H-Proline incorporation method were used to study the effects of plant flavones on fibroblast proliferation and collagen composation.RESULTS:With the change of dosage,these flavones inhibited the fibroblats proliferation and intracellular collagen composation.But they did not influnce the excellular collagen volume.CONCLUSION:It showed that Z-1 and Z-2 had definite effects of antifibrosis.The seplant flavones may offer a new way to antifibrosis.
Key words
Erigeron bonariensis /
fibrosis /
fibroblast proliefration /
collagen composation
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References
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