Abstract
OBJECTIVE:To screen and isolate immunosuppressants from microorganisms.METHODS:Using yeast systemin vitro,we screened the metabolites of microorganisms and found the strains with immunosuppressant activity.Pure active compounds were obtained by fermentation,solvent extraction,solica gel chromatography etc.The chemical structures were elucidated through analyses of physico-chemical properties,MS,IR,UV,NMR spectra,respectively.RESULTS:Two isoflavone compounds were isolated from the strain 800.Their structures were elucidated.CONCLUSION:Microorganisms can synthesize isoflavone compounds.
Key words
immunosuppressant compounds /
isoflavone /
spectrum analysis /
yeasts
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Hu Hifeng .
Studies on SIP-800-2 and 3,immunosuppressants from microorganisms[J]. Chinese Pharmaceutical Journal, 1999, 34(09): 622-623
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