Pharmacokinetics and pharmacodynamics of lidocaine carbonate in patients during epidural anesthesia
Zhang Yi
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(Zhang Y)，Jin Zhiqiang (Jin ZQ)，Lü Libo(Lü LB)，et a
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Received
Published
1998-08-18
1999-09-05
Issue Date
1999-09-05
Abstract
OBJECTIVE:Pharmacokinetics and pharmacodynamics of lidocaine carbonate in patients during epidural anesthesia were investigated.METHODS:There were 15 patients performed epidural anesthesia enroed in this study.Serum levels of lidocaine and plasma renin concentrations were measured using FPIA and RIA,respectively.Pharmacodynamics was evaluated by subjective observation of an anesthetist and was assessed indirectly by plasma renin levels.The results of pharmacokinetics and pharmacodynamics of lidocaine carbonate were compared with those of lidocaine hydrochloride.RESULTS:The peak time,the maximal concentrations,constant of absorption rate and half life were (0.30±0.04)min,(3.96±1.14)mg·L-1,(10.92±2.36)h-1 and (1.95±0.08)h,respectively.Blockade,the onset time,finished time and persistent time of blockade were (4.38±0.78)min,(8.23±1.84)min and (57.22±10.35)min,respectively.CONCLUSION:The results shown constant of absorption rate of lidocaine carbonate was singificantly bigger than that of lidocaine hydrochloride;the peak time was shorter than that of lidocaine hydrochloride too;half life of lidocaine carbonate was almost identical with that of lidocaine hydrochloride.Onset time and finished time of blockade of lidocaine carbonate were shorter than those of its hydrochloride.The study suggested that onset of blockade of lidocaine carbonate was faster,but elimination of lidocaine in human body was not changed during epidural anesthesia.
Zhng Yi .
Pharmacokinetics and pharmacodynamics of lidocaine carbonate in patients during epidural anesthesia[J]. Chinese Pharmaceutical Journal, 1999, 34(09): 610-613
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