Application of grey theory in predicting methotrexate loaded nanocapsules long period release in vitro
Wei Min
Author information+
(Wei M)，Chang Jin (Chang J)，Yao Kangde(Yao KD
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History+
Received
Published
1999-04-22
1999-09-05
Issue Date
1999-09-05
Abstract
OBJECTIVE:Grey theory,a kind of statistics method,was explored to predict long period drug release.Its validity was demonstrated.METHODS:By using grey theory,the GM(1,1) math model of drug release was constructed according to short time release data and employed to forecast long period release of methotrexate (MTX) from nanocapsules,attached with computer data processing.At the same time,the difference between factual value and predicting value was analyzed.By this way,this method was evaluated.RESULTS:The study showed that the math model may predict the release effectively and the result errors were satisfying.CONCLUSION:Grey theory can be used to precisely predict long period drug release process.
Wei Min .
Application of grey theory in predicting methotrexate loaded nanocapsules long period release in vitro[J]. Chinese Pharmaceutical Journal, 1999, 34(09): 605-607
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References
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