Abstract
OBJECTIVE:To observe the stimulant effects of ethylacetate extract ofTripterygium wilfordii(TWEE) on adrenal cortex in rat.METHOD:Oral administration of TWEE 25mg·kg-1.bid were given to SD rats for 30 days.The serum corticosterone was determined and the histology,ultrastructure of adrenal glands were observed.RESULTS:After 30 days administration,the serum corticosterone level was markedly increased in the TWEE group.The fascicular zone in adrenal cortex markedly became thick and the plasma filled with lipoid vesicles.The cell plasma of fascicular zone contained a great deal of mitochondria,smooth endoplasmic reticulum and lipid droplets observed by transmission electron microscopy.The cristae of mitochondria were vacuolar.CONCLUSION:TWEE can promote the production of corticosterone and the proliferation of the cell of fascicular zone in adrenal cortex in SD rat.
Key words
ethylacetate extract of Tripterygium wilfordii(TWEE) /
prednisone /
transmission electron microscopy
{{custom_keyword}} /
Cite this article
Download Citations
Chen Long.
The effects of ethylacetate extract of Tripterygium wilfordii on adrenal glands in rats[J]. Chinese Pharmaceutical Journal, 1999, 34(09): 592-594
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
1 李乐真，陈芍芳，谭宫屏，等．雷公藤提取物对垂体-肾上腺皮质系统的影响．中成药研究，1983，10:23．
2 李玉敏，魏韵韶．雷公藤对小鼠肾上腺结构的影响．第一军医大学学报，1989，9(3)：247．
3 Zhang M M，Liu P L，Ye W Y．Effect of Tripterygium wilfordii on adrenal cortex in rat with adjuvant arthritis．J Tongji Med Uni，1994，14(3)：158．
4 胡大伟，刘沛霖．雷公藤与强的松药理作用的互补性．中国中西医结合杂志，1997，17(2)：94．
5 周广耀，宾陈玉，田鄂华．雷公藤对类风湿性关节炎患者肾上腺皮质功能影响的初步研究．中国医院药学杂志，1983，3(4)：5．
6 倪宗瓒主编．医学统计学．北京：人民卫生出版社，1990：108～141．
7 邓文龙，聂仁吉，刘家玉．昆明山海棠的药理作用研究I．抗炎作用及对垂体-肾上腺皮质系统功能的影响．中草药，1981，12(8)：22．
8 钱起丰．雷公藤对豚鼠变应性及毒性接触性皮炎作用的实验研究．中华皮肤科杂志，1985，18(1)：2．
9 周广耀．雷公藤的临床生化及生化药理研究进展．中国医院药学杂志,1989，9(7)：320．
10 罗邦尧主编．肾上腺疾病诊断与治疗学．上海：上海科技教育出版社。1995：132．
11 蔡定芳，沈自尹，张玲娟，等．右归饮对大鼠下丘脑-垂体-肾上腺胸腺轴抑制模型的影响．中国免疫学杂志，1994，10(4)：236．
12 Gwosdow-Cohen A，Chen CL，Besch EL．Radioimmunoassay(RIA) of serum Corticosterone in rats．Proc Soc Expl Biol Med，1982，170：29～34．
{{custom_fnGroup.title_en}}
Footnotes
{{custom_fn.content}}
