OBJECTIVE :To estabolish an assay for the determination of chlorzoxazoni and paracetamol in Co-chlorzoxazoni tablet. METHOD: CPA-Matrix and Multi-Wavelength Linear regression method were used at the same time.The calculatiue compater program was edited by BASIC.RESULTS: The average recovery and RSD of chlorzoxazoni and paracetamol were 99.83%and 0.12%,99.87% and 0.14% for CPA-Matrix mothod,were 98.67% and 0.34%,100.05% and 0.31% (n=5) for Multi-Wavelength Linear regression method. CONCLUSION: These methods are simple,rapid and satisfied.