Abstract
OBJECTIVE: To estiblish quality control method for Liuwei Muxiang capsule. METHODS: Its ingredients,geniposide,Radix Aucklandiae,Flos Rhododendri Mollis,Fructus Piperis Longi,were identified by TLC.A thin-layer densitometry for determining geniposide,the main effective component from Fructus Gardeniae in the capsule was investigated. RESULTS: The identified characteristics of the chromatography were distinct and easily distinguished;The determining method was linear over the range of 15g with the average recovery 95.3% and the RSD 4.8% β-sitosterol and rhodojaponin-Ⅲ,were isolated from the flowers of Rhododendron molle G.Don (Flos Rhododendri Mollis) for the first time. CONCLUSION:BZThe quality standard of the capsule was provided.The method for identification and determination is simple,reproducible and practical.The rhodojaponin-Ⅲ from the flowers and the rhometoxin from the fruits are the same compound.Its content of the flowers is 0.3 g·g-1 only,much lower than that of the fruits.
Key words
Liuwei Muxiang capsule /
geniposide /
TLC /
determination /
Flos Rhododendri Mollis /
rhodojaponin-Ⅲ/rhometoxin
{{custom_keyword}} /
Cite this article
Download Citations
Cong Xiodong.
Studies on quality standard of Liuwei Muxiang capsule[J]. Chinese Pharmaceutical Journal, 1999, 34(08): 552-555
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
1 苏健，王宝琴．复方栀子冲剂栀子苷薄层扫描测定．中成药，1993，15(1)：16．
2 唐盈．高效薄层扫描测定栀子及其制剂中京尼平苷的含量．中成药研究，1988，10(6)：14．
3 童玉懿，章观德，相长和彦，等．栀子及其制剂中栀子苷的高压液相色谱分析．中国中药杂志，1989，14(4)：36．
4 Hikino H，Ito K，Ohta T，et al．Stereostructure of Rhodojaponin I，II and llI，Toxins of Rhododendron japonicum，and of AsebotoxinⅢ，Toxins of Pierls japonica．Chem Pharm Bull，1969，17(5)：1078.
5 Hikino H，Ogura M，Ohta T，el：al．Stereostructure of Asebotoxin，and Rhodojaponins，Toxins of Ericaceae，Chem Pharm Bull,1970，18(5)：1071．
6 濮全龙．羊踯躅中闹羊花毒素Ⅲ的结构测定．中草药，1993，14(7)：5．
7 武汉医学院附一院药剂科中草药小组．八厘麻毒素的提取分离及其药用标准．武汉医学院学报，1979，8(1)：44．
8 武汉医学院附一院药剂科中草药小组．八厘麻毒素的精制和结构鉴定．医院药学杂志，1981，1(3)：7．
9 江苏新医学院编．中药大辞典．上海：上海科学技术出版社，1979，1447．
{{custom_fnGroup.title_en}}
Footnotes
{{custom_fn.content}}
