Preparation of BSA-propranolol microspheres and its quality evaluation

Zhng Qizhi

Chinese Pharmaceutical Journal ›› 1999, Vol. 34 ›› Issue (05) : 308-301.

Chinese Pharmaceutical Journal ›› 1999, Vol. 34 ›› Issue (05) : 308-301.
药剂

Preparation of BSA-propranolol microspheres and its quality evaluation

  • Zhang Qizhi
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Abstract

OBJECTIVE:To study the preparation of BSA-propranolol hydrochloride microspheres (PRO-AM) and evaluate its quality.METHODS:The microspheres were prepared by an emulsion-heat stabilization technique.The morphology of PRO-AM,the drug loading and the release characteristics in vitro were studied.The effects of microspheres on ciliary movement were evaluated in vitro with toad palate model.RESULTS:The microspheres were spherical with size of 1~10μm and drug loading of 4.05%.The drug release was observed up to 85.5% within 24h.While PRO-AM was applied to the upper palate of toad for 4h,more than 70% ciliary moved lively,but all ciliary died 5min after applying PRO solution.CONCLUSION:The preparation of propranolol hydrochloride microspheres seems to decrease the ciliotoxicity of PRO.

Key words

propranolol hydrochloride / albumin microspheres / ciliotoxicity

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Zhng Qizhi. Preparation of BSA-propranolol microspheres and its quality evaluation[J]. Chinese Pharmaceutical Journal, 1999, 34(05): 308-301

References

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