Preparation of BSA-propranolol microspheres and its quality evaluation
Zhang Qizhi
Author information+
(Zhang QZ),Jiang Xinguo(Jiang XG),Yang Cheng(Yang C),et a
{{custom_zuoZheDiZhi}}
{{custom_authorNodes}}
{{custom_bio.content}}
{{custom_bio.content}}
{{custom_authorNodes}}
Collapse
History+
Received
Published
1998-12-10
1999-05-05
Issue Date
1999-05-05
Abstract
OBJECTIVE:To study the preparation of BSA-propranolol hydrochloride microspheres (PRO-AM) and evaluate its quality.METHODS:The microspheres were prepared by an emulsion-heat stabilization technique.The morphology of PRO-AM,the drug loading and the release characteristics in vitro were studied.The effects of microspheres on ciliary movement were evaluated in vitro with toad palate model.RESULTS:The microspheres were spherical with size of 1~10μm and drug loading of 4.05%.The drug release was observed up to 85.5% within 24h.While PRO-AM was applied to the upper palate of toad for 4h,more than 70% ciliary moved lively,but all ciliary died 5min after applying PRO solution.CONCLUSION:The preparation of propranolol hydrochloride microspheres seems to decrease the ciliotoxicity of PRO.