Comparison experimental therapeutic effect of two topical drugs in two animal models
Chen Qiong
Author information+
(Chen Q)，Zhu Xuejun(Zhu XJ)，Yang Haizhen(Yang HZ)，et a
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History+
Received
Published
1997-04-07
1998-06-05
Issue Date
1998-06-05
Abstract
OBJECTIVE: To compare experimental therapeutic effect of two topical drugs in two animal models. METHOD: The authors used two kinds of animal experimental models, mouse vaginal epithelium in estrus cycle and mouse tail scaled epidermis to assess the effect of clobetasol-17-propionate and triamcinolone acetonide on epithelial mitosis and epidermal keratinization respectively. RESULTS: There is not significant difference between clobetasol-17- propionate and triamcinolone acetonide about inhibiting the mitosis in mouse vaginal epithelium (P>0.05). There is significant difference between clobetasol-17-propionate and triamcinolone acetonide about promoting the formation of granular layer in scale epidermis of mouse tail (P<0.05). CONCLUSION: The effect of clobetasol-17-propionate and triamcinolone acetonide on epithelial mitosis are similar. Their effect on promoting the formation of granular layer in scale epidermis of mouse tail is that clobetasol-17-propionate is better than triamcinolone acetonide.
Chen Qiong.
Comparison experimental therapeutic effect of two topical drugs in two animal models [J]. Chinese Pharmaceutical Journal, 1998, 33(06): 340-342
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References
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