OBJECTIVE: To monitor the distribution of pathogenic bacteria separated in clinics and their resistance . METHODS: Cefinase paper was used in the β-lactamase property analysis of pathogenic bacteria .Drug sensitivity was judged using KirbyBbuer agar diffusion method. RESULTS : 539 pathogenic bacteria were separated from in patients in 1996. Among them, 19% were Grampositive and 81% Gramnegative. The total zymogenic rate was 80%. The drug resistance rate of thirdcephalosporins, cefuroxime and amikacin to Staphylococcus aureus was lower than that of firstcephalosporins and penicillin. The drug resistance rate of cefoperazone/subactam, ceftazidime, amikacin and gentamicin to Gramnegative rods was low. CONCLUSION: The drug resistance rate of fluoroqinolones to Enterococcus rods is relatively high, and with cross resistance with other antibiotics.