The technology of preparation of poly (DL-lactide) aclacinomycin nanoparticle
He Lin
Author information+
(He L)，Jiang Xuehua(Jiang XH)，Li Tun(Li T
{{custom_zuoZheDiZhi}}
{{custom_authorNodes}}
{{custom_bio.content}}
{{custom_bio.content}}
{{custom_authorNodes}}
Collapse
History+
Received
Published
1997-04-07
1998-05-05
Issue Date
1998-05-05
Abstract
OBJECTIVE: To prepare the poly (DL-lactide) aclacinomycin nanoparticle in order to evaluate the nanoparticle delivery system and to develop the pharmaceutics of aclacinomycin nanoparticle. METHODS: An optimal design was selected to establish the optimal condition, and the interfacial polymerization method was used to prepare the nanoparticle system. RESULTS: The mean diameter of the nanoparticle was 80 nm, the mean drug loading was 18.5%, and the drug embedding ratio was 86.7%. CONCLUSION: The technology of preparation of poly (DL-lactide) aclacinomycin nanoparticle is practicable and successful.
