Abstract
OBJECTIVE: To prepare the poly (DL-lactide) aclacinomycin nanoparticle in order to evaluate the nanoparticle delivery system and to develop the pharmaceutics of aclacinomycin nanoparticle. METHODS: An optimal design was selected to establish the optimal condition, and the interfacial polymerization method was used to prepare the nanoparticle system. RESULTS: The mean diameter of the nanoparticle was 80 nm, the mean drug loading was 18.5%, and the drug embedding ratio was 86.7%. CONCLUSION: The technology of preparation of poly (DL-lactide) aclacinomycin nanoparticle is practicable and successful.
Key words
aclacinomycin A /
poly (DL-lactide) /
nanoparticle
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He Lin.
The technology of preparation of poly (DL-lactide) aclacinomycin nanoparticle[J]. Chinese Pharmaceutical Journal, 1998, 33(05): 289-291
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