Analgin nasal absorption

Mo Shirui

Chinese Pharmaceutical Journal ›› 1997, Vol. 32 ›› Issue (02) : 87-90.

Chinese Pharmaceutical Journal ›› 1997, Vol. 32 ›› Issue (02) : 87-90.
药剂

Analgin nasal absorption

  • Mao Shirui
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Abstract

OBJECTIVE: To investigate the regulation of analgin nasal absorption. METHODS: We used rat in situ nasal recirculation methods as experimental model. The effects of perfusion volume, flow rate, perfusion concentration on nasal absorption of analgin were studied. RESULTS: The larger the perfusion volume, the little of the percent absorbed each minute. At first, the absorption rate constant K increased with the increase of flow rate, K decreased significantly while the flow rate was over 2 ml·min-1，keeping the perfusion volume 3 ml and flow rate 2 ml·min-1 as a rule, we studied nasal absorption regulation of four concentration: 50, 100, 150, 200 g·L-1, indicating that the absorption rate of different concentration is a constant. CONCLUSION: The mechanism of analgin nasal absorption is passive diffusion, following first-order kinetics, the absorption rate constant is 0.022 19min-1.

Key words

analgin / in situ nasal recirculation method / nasal mucosa / absorption rate constant

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Mo Shirui. Analgin nasal absorption[J]. Chinese Pharmaceutical Journal, 1997, 32(02): 87-90

References

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