The effectiveness of oral administration of insulin microspheres(IMS) was evaluated in alloxan-treated diabetic rabbits. Three doses were tested. The blood glucose levels were determined enzymatically by using the method of glucose oxidase. A significant difference in blood glucose level was noted after use of 6 u/20 g IMS when compared to control groups,and maintained for 5 hours.The hypoglycemic effect was linear with the doses of IMS within the range of 7.0u/20g～4.0u/20g. The findings may be of significance in the search for a suitable oral administration for insulin or perhaps other proteinaceous substances.
Wng Siling;Su Desen;Zhng Jinghi;Yu Qin;Liu Yuln.
The hypoglycemic effect of insulin oral microspheres in alloxan-treated diabetic rabbits[J]. Chinese Pharmaceutical Journal, 1995, 30(S1): 12-14
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