Thermal analysis studies on formulation composition of tablets of bendazac lysine

MO Hu;LU in

Chinese Pharmaceutical Journal ›› 1994, Vol. 29 ›› Issue (10) : 616-620.

Chinese Pharmaceutical Journal ›› 1994, Vol. 29 ›› Issue (10) : 616-620.
药品质量及检验

Thermal analysis studies on formulation composition of tablets of bendazac lysine

  • MAO Hua;LU Bin
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Abstract

Differential scanning colorimetry(DSC) was used to screen out best excipientswhich do not interact with bendazac lysine(BZL).According to the preformulation studies,for-mulation composition and preparation of ordinary tablets have been designed. The humidificationof BZL was improved. The cumulative dissolution in 20min of the tablets was 98. 84%±0. 64%.Using thermogravimetry analysis(TGA ) method the activation energies of thermal degradationwere found to be 116±13(BZL) and 126±7(tablets)kJ/mol,respectively,which are not obviously different.On the other hand,the appearance and the content of the tablets had no change after three months of storage at 37℃ and 75% RH.

Key words

bendazac lysine / differential scanning colorimetry / critical relative humidity / ther-mograviemetry analysis

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MO Hu;LU in. Thermal analysis studies on formulation composition of tablets of bendazac lysine[J]. Chinese Pharmaceutical Journal, 1994, 29(10): 616-620

References

1Silvestrini B,Catanese B, Lisciani R,et al.Studies on the mechanism of action of bendazac.Arzneimittelforsch,1970.50:252. 2Sivestrini B,Baiocchi L.Bendazac composition for treatment of cataract.UK Patent Application GB 2110532A.1983-06-22 3潘悌摘。DSC法研究盐酸氧烯洛尔、替马西渊与片剂赋形剂间的相容性[英].国外医学.药学分册,1990,17(6):373. 4金守礼.高分子材料热寿命快速评定方法的基础理论。工程塑料技术,1980,3:28

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