We studied sustained release characteristics of sodium alginate( NaAlg),chitosan(CS)and their mixture,incorporation with propafenone hydrochloride(PF)as a model drug.Theresults showed that the sustained release effect of the mixed matrix of NaAlg and CS was the bestamong the three matrices studied,being less affected by pH value of the dissolution medium andyet performing an approximatly constant release rate in artificial gastro-enteric medium when theratio of NaAlg to CS was 1:1 or 3 :2 in the mixed matrix.
Key words
sodium alginate /
chitosan /
propafenone hydrochloride /
sustained release matrixtablet /
sustained release effect
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References
1奚念朱，屠之培，裴元英，等.海藻酸钙作为缓释片的骨架材料的研究.药学学报,1981，16(4) ： 277.
2Pepperman AB, Kuan JCW. Alginate controlled release formulation of melribuzin. J Controlled Release, 1991，17 (1)：105.
3Kanke M, Katayama H，Tsuzuki S, et al. Application of chitin and chitosan to pharmaceutical preparetion. Chem Pharm Bull, 1989,37(2) : 523.
4Takahashi T,Takayama K,Machida Y,et al. Characteristics of polyion complexes of chitosan with soeium alginate and sodium polyacrylate. Int J Pharm, 1990,61 ( 1，2 ):35.
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Footnotes
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