Diclofenac sodium can be released continuously from hydrophilic and insolublematrices for more than 12 hours in vitro. The mechanism of hydrophilic matrix is first-orderkinetics,lg(1-F)=0.1865-0.1177t,r=-0.9928 and that of insoluble matrix is the square rootkinetics,F=0. 3226t1/2-0.1503,r=0.9916.Medium pH affects significantly the release rate ofDiclofenal sodium, There is no notable effect in stirring rate between 50 and 100 r/min for therelease rate of Diclofenal sodium.
Key words
hydrophilic matrix /
insoluble matrix /
Dlclofenac sodium /
release mechanism
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References
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Footnotes
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