Cyclosporin A oitment was prepared with Azone and propane-1,2-diol,Which act-ed as penetrative accelerants。 Its composition was designed by orthogonal test. The percutaneousrelease rate of the ointment was determined in vitro with Holland pig′s skin and cadaver skin。 Theresults showed that accumulative release rate of excellent formulation of cyclosporin A was satis-factory.
Key words
cyclosporin A /
in vitro percutaneous penetration /
orthogonal test
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References
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2Susan Budavari.The Merck Index,ed 11.USA：Merck and Co，inc,1989:431.
3Kevin D.Mechanisms of cyclosporin A inhibition of anti-gen-presenting activity in uninvoled and lesional psoriatic epidermis.J Invest Dermatol f 1990,9:649.
4Egbaria K.Topical delivery of cyclosporin.J Skin Pharmacol,1990,3(l):21.
5Christopher E M.Cyclosphilin content of normal and pso-riatic epidermis.J Invest Dermatol,1990,94(4):436.
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Footnotes
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