Effects of SOD activity in the environment of stomach and small in-testines
CUI Yu-min;ZHANG Bing-ran;YUAN Qin-sheng
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East China University of Science and Techonology ;Shanghai 200237
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History+
Received
Published
1993-03-09
1994-08-05
Issue Date
1994-08-05
Abstract
SOD(superoxide dismutase)is absorpted in rat stomach and small intestines after itis taken orally.The inactivating effects on SOD,includirig hydrochloric acid in stomach and pro-teinases in stomach and small intestines,are measured. The remaining activities of SOD were84.0%in the hydrochloric acid reacting for 120 minutes,82.3%in the solution of pepsin reactingfor the same time and 83.1%in the solution of pancreatin reacting for 210 minutes。 The resultdemonstrates that SOD has strong resistance to the inactivating effects of imitated stomach andsmall intestines.
CUI Yu-min;ZHNG ing-rn;YUN Qin-sheng.
Effects of SOD activity in the environment of stomach and small in-testines[J]. Chinese Pharmaceutical Journal, 1994, 29(08): 464-466
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References
1Malinowski DP,Fridovich I.Subunit association and side-chain reactivities of bovine erythrocyte superoxide dismu-tase in denaturing solvents.Biochemistry ,1988,18:5055.
2谢卫华，姚菊芳，袁勤生.连苯三酚自氧化法测定超氧化物歧化酶活性的改进.医药工业,1988,19：217.
