果蝇在药理学研究中的应用

段丹丹,高丽,秦雪梅,周玉枝,杜冠华

中国药学杂志 ›› 2016, Vol. 51 ›› Issue (19) : 1638-1642.

PDF(778 KB)
PDF(778 KB)
中国药学杂志 ›› 2016, Vol. 51 ›› Issue (19) : 1638-1642.
综述

果蝇在药理学研究中的应用

  • 段丹丹1a,1b,高丽1a*,秦雪梅1a*,周玉枝1a,杜冠华2
作者信息 +

Application of Drosophila melanogaster in Pharmacological Research

  • DUAN Dan-dan1a,1b, GAO Li1a*, QIN Xue-mei1a*, ZHOU Yu-zhi1a, DU Guan-hua2
Author information +
文章历史 +

摘要

果蝇作为一种模式生物,具有生命周期短、繁殖力强、基因保守性高等特点。目前,果蝇已广泛应用于药理学和疾病机制研究中,涵盖衰老、神经退行性疾病、失眠、肿瘤等领域,在加快药物筛选速度和靶点发现等方面显示出潜在的应用价值。笔者就果蝇作为模式生物的优势、在药理学研究中的应用及局限性3个方面展开综述。

Abstract

As a model organism, Drosophila melanogaster has the characteristics of short life cycle, high fecundity and high gene conservation. At present, Drosophila melanogaster has been widely used in the studies of pharmacology and pathogenesis, including aging, neurodegenerative disease, insomnia, tumor and other fields, which show potential values in accelerating the speed of drug screening and target discovery. In this paper, the advantages of Drosophila as a model organism, the applications and limitations of Drosophila in pharmacological studies were reviewed.

关键词

果蝇 / 衰老 / 神经退行性疾病 / 失眠 / 肿瘤 / 药物发现

Key words

Drosophila melanogaster / aging / neurodegenerative disease / insomnia / tumor / drug discovery

引用本文

导出引用
段丹丹,高丽,秦雪梅,周玉枝,杜冠华. 果蝇在药理学研究中的应用[J]. 中国药学杂志, 2016, 51(19): 1638-1642
DUAN Dan-dan, GAO Li, QIN Xue-mei, ZHOU Yu-zhi, DU Guan-hua. Application of Drosophila melanogaster in Pharmacological Research[J]. Chinese Pharmaceutical Journal, 2016, 51(19): 1638-1642
中图分类号: R965   

参考文献

[1] RUBIN G M, LEWIS E B. A brief history of Drosophila′s contributions to genome research . Science, 2000, 287(5461):2216-2218.
[2] PANDEY U B, NICHOLS C D. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery . Pharmacol Rev, 2011, 63(2):411-436.
[3] GHOSH M, SONKAR S K, SAXENA M, et al. Carbon nano-onions for imaging the life cycle of Drosophila melanogaster . Small, 2011, 7(22):3170-3177.
[4] RAND M D. Drosophotoxicology:the growing potential for Drosophila in neurotoxicology . Neurotoxicol Teratol, 2010, 32(1):74-83.
[5] INAMDAR A A, CHAUDHURI A, O′DONNELL J. The protective effect of minocycline in a paraquat-induced Parkinson′s disease model in Drosophila is modified in altered genetic backgrounds . Parkinsons Dis, 2012, 2012:938528.
[6] HOWLETT I C, TANOUYE M A. Seizure-sensitivity in Drosophila is ameliorated by dorsal vessel injection of the antiepileptic drug valproate . J Neurogenet, 2013, 27(4):143-150.
[7] ADAMS M D, CELNIKER S E, HOLT R A, et al. The genome sequence of Drosophila melanogaster . Science, 2000, 287(5461):2185-2195.
[8] LLOYD T E, TAYLOR J P. Flightless flies:Drosophila models of neuromuscular disease . Ann N Y Acad Sci, 2010, 1184:e1-20.
[9] REITER L T, POTOCKI L, CHIEN S, et al. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster . Genome Res, 2001, 11(6):1114-1125.
SHEN L R, XIAO F, YUAN P, et al. Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila . Age, 2013, 35(4):1133-1142.
NAVROTSKAYA V V, OXENKRUG G, VOROBYOVA L I, et al. Berberine prolongs life span and stimulates locomotor activity of Drosophila melanogaster . Am J Plant Sci, 2012, 3(7A):1037-1040.
KIM M S. Korean red ginseng tonic extends lifespan in D. melanogaster . Biomol Ther, 2013, 21(3):241-245.
MORA M, BONILL E, MEDINA-LEENDERTZ S, et al. Minocycline increases the activity of superoxide dismutase and reduces the concentration of nitric oxide, hydrogen peroxide and mitochondrial malondialdehyde in manganese treated Drosophila melanogaster . Neurochem Res, 2014, 39(7):1270-1278.
LIN W S, CHEN J Y, WANG J C, et al. The anti-aging effects of ludwigiaoctovalvis on Drosophila melanogaster and SAMP8 mice . Age, 2014, 36(2):689-703.
HEINRICHSEN E T, HADDAD G G. Role of high-fat diet in stress response of Drosophila . PLoS One, 2012, 7(8):e42587.
BOYD O, WENG P, SUN X, et al. Nectarine promotes longevity in Drosophila melanogaster . Free Radic Biol Med, 2011, 50(11):1669-1678.
WANG C, WHEELER C T, ALBERICO T, et al. The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster . Age, 2013, 35(1):69-81.
CASTRO J P, CARARETO C M. Drosophila melanogaster P transposable elements:mechanisms of transposition and regulation . Genetica, 2004, 121(2):107-118.
BRAND A H, PERRIMON N. Targeted gene expression as a means of altering cellfates and generating dominant phenotypes . Development, 1993, 118(2):401-415.
LIU Y, ZHANG M C, WEI Y H, et al. The application of the GAL4/UAS system in the Drosophila Tis11RNA interference . Life Sci Res (生命科学研究), 2012, 16(3):207-211.
MUQIT M M, FEANY M B. Modelling neurodegenerative diseases in Drosophila:a fruitful approach? . Nat Rev Neurosci, 2002, 3(3):237-243.
WAN Y Q, XIE W. Drosophila:an important model organism for understanding basic biological and human disease mechanisms . Chin Bull Life Sci(生命科学), 2006, 18(5):425-429.
WILLIAMSON J, GOLDMAN J, MARDER K S. Genetic aspects of Alzheimer disease . Neurologist, 2009, 15(2):80-86.
YAARI R, COREY-BLOOM J. Alzheimer′s disease . Semin Neurol, 2007, 27(1):32-41.
VOSSEL K A, ZHANG K, BRODBECK J, et al. Tau reduction prevents Abeta-induced defects in axonal transport . Science, 2010, 330(6001):198.
WANG J J, WANG M, ZHANG L H, et al. Construction of Aβ42 transgenic AD flies and their applications in drug screening . Chin J Cell Biol(中国细胞生物学学报), 2014, 36(6):745-751.
WANG L, CHIANG H C, WU W, et al. Epidermal growth factor receptor is a preferred target for treating amyloid-beta-induced memory loss . Proc Natl Acad Sci USA, 2012, 109(41):16743-16748.
MHATRE S D, MICHELSON S J, GOMES J, et al. Development and characterization of an aged onset model of Alzheimer′s disease in Drosophila melanogaster . Exp Neurol, 2014, 261:772-781.
DUFFY J B. GAL4 system in Drosophila:a fly geneticist′s Swiss army knife . Genesis, 2002, 34(1-2):1-15.
WANG X, PERUMALSAMY H, KWON H W, et al. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer′s disease . Sci Rep, 2015, 5:16127.
POLYMEROPOULOS M H, LAVEDAN C, LEROY E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson′s disease . Science, 1997, 276(5321):2045-2047.
KITADA T, ASAKAWA S, HATTORI N, et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism . Nature, 1998, 392(6676):605-608.
BONIFATI V, RIZZU P, SQUITIERI F, et al. DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism . Neurol Sci, 2003, 24(3):159-160.
VALENTE E M, ABOU-SLEIMAN P M, CAPUTO V, et al. Hereditary early-onset Parkinson′s disease caused by mutations in PINK1 . Science, 2004, 304(5674):1158-1160.
PAISAN-RUIZ C, JAIN S, EVANS E W, et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson′s disease . Neuron, 2004, 44(4):595-600.
RAGLAND M, HUTTER C, ZABETIAN C, et al. Association between the ubiquitin carboxyl-terminal esterase L1 gene (UCHL1) S18Y variant and Parkinson′s disease:a HuGE review and Meta-analysis . Am J Epidemiol, 2009, 170(11):1344-1357.
KRUGER R, KUHN W, MULLER T, et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson′s disease . Nat Genet, 1998, 18(2):106-108.
SIDDIQUE Y H, NAZ F, JYOTI S. Effect of curcumin on lifespan, activity pattern, oxidative stress, and apoptosis in the brains of transgenic Drosophila model of Parkinson′s disease . Biomed Res Int, 2014, 2014:606928.
SIDDIQUE Y H, JYOTI S, NAZ F. Effect of epicatechingallate dietary supplementation on transgenic Drosophila model of Parkinson′s disease . J Diet Suppl, 2014, 11(2):121-130.
JANSEN R L, BROGAN B, WHITWORTH A J, et al. Effects of five ayurvedic herbs on locomotor behaviour in a Drosophila melanogaster Parkinson′s disease model . Phytother Res, 2014, 28(12):1789-1795.
HENDRICKS J C, KIRK D, PANCKERI K, et al. Modafinil maintains waking in the fruit fly drosophila melanogaster . Sleep, 2003, 26(2):139-146.
ANDRETIC R, KIM Y C, JONES F S, et al. Drosophila D1 dopamine receptor mediates caffeine-induced arousal . Proc Natl Acad Sci USA, 2008, 105(51):20392-20397.
YANG B, ZHANG A, SUN H, et al. Metabolomic study of insomnia and intervention effects of suanzaoren decoction using ultra-performance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry . J Pharm Biomed Anal, 2012, 58:113-124.
YANG B, ZHANG A H, WANG H. The experimental study of suanzaorensaponin A, B in the treatment of insomnia based on Drosophila model . Inf Tradit Chin Med (中医药信息), 2013, 30(5):55-57.
GONZALEZ C. Drosophila melanogaster:a model and a tool to investigate malignancy and identify new therapeutics . Nat Rev Cancer, 2013, 13(3):172-183.
DAS T, CAGAN R. Drosophila as a novel therapeutic discovery tool for thyroid cancer . Thyroid, 2010, 20(7):689-695.
WILLOUGHBY L F, SCHLOSSER T, MANNING S A, et al. An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery . Dis Model Mech, 2013, 6(2):521-529.
BIRSE R T, CHOI J, REARDON K, et al. High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila . Cell Metab, 2010, 12(5):533-544.
CANAVOSO L E, JOUNI Z E, KARNAS K J, et al. Fat metabolism in insects . Annu Rev Nutr, 2001, 21:23-46.
PIAZZA N, WESSELLS R J. Drosophila models of cardiac disease . Prog Mol Biol Transl Sci, 2011, 100:155-210.

基金

山西大学引进人才事业发展经费资助项目(226545008,226545003);2015年度山西省高等学校科技创新项目(2015118)
PDF(778 KB)

202

Accesses

0

Citation

Detail

段落导航
相关文章

/