中药药动学研究中给药剂量的现状分析

黄娟萍,罗裕,江力,梁锦杰,谢吉福,朱盛山

中国药学杂志 ›› 2012, Vol. 47 ›› Issue (21) : 1685-1689.

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中国药学杂志 ›› 2012, Vol. 47 ›› Issue (21) : 1685-1689.
综述

中药药动学研究中给药剂量的现状分析

  • 黄娟萍,罗裕,江力,梁锦杰,谢吉福,朱盛山
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文章历史 +

摘要

目的 对药动学研究中给药剂量情况进行综述,并对其中存在的问题进行讨论,为今后进行药动学研究提供参考。方法 检索、查阅国内外近年来药动学研究文献与著作,并对单味中药、单方制剂、中药复方、单体药物的药动学口服给药剂量进行列表分析。结果 各类药物在进行药动学实验时,给药剂量与人体实际服用量间存在一定的差异,给药剂量往往比人体实际服用剂量大很多。结论 不同剂量药物的体内过程往往不一样,而且药物在人体的代谢存在饱和现象,加大给药剂量考察药物的体内过程,并不能直接反映药物在人体的体内过程。

关键词

药动学 / 给药剂量 / 中药 / 单体药物

引用本文

导出引用
黄娟萍,罗裕,江力,梁锦杰,谢吉福,朱盛山. 中药药动学研究中给药剂量的现状分析[J]. 中国药学杂志, 2012, 47(21): 1685-1689
中图分类号: R971   

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基金

基金项目:国家自然科学基金资助项目(30973954)
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