OBJECTIVE To review the efficacy and safety of ambroxol for lung protection in perioperative period. METHODS Random controlled trails (RCTs)， systematic review (SR)， and meta-analysis of ambroxol for lung protection in perioperative period were searched in Cochrane， PubMed， Embase， ISI， CBMdisc， CNKI， VIP and Wangfang dababase； the methodology quality of every RCT was evaluated， then meta-analysis was performed by software of RevMan5.0.0. RESULTS Twelve RCTs of ambroxol for lung protection in perioperative period were included. According to the meta-analysis results， the ambroxol group was better than the control group in pulmonary complications [RR 0.55，95%CI (0.40， 0.74)， P=0. 000 1]， The cough and expectoration degree in the ambroxol group was better than the control group [RR 1.25，95%CI (1.09， 1.44)， P=0.001]. The ambroxol group was also better than the control group in sputum volume [RR 1.24，95%CI(1.12， 1.38)， P
SU Na，WU Bin， LU Jing，XU Ting.
Efficacy and Safety of Ambroxol for Lung Protection in Perioperative Period： A Systematic Review[J]. Chinese Pharmaceutical Journal, 2012, 47(14): 1154-1157
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