目的 研究虎耳草科植物绣球花［Hydrangea macrophylla(Thunb. Seringe］的化学成分。方法 利用Diaion HP-20， Toyopearl HW-40， 硅胶等柱色谱技术进行分离纯化， 根据化合物的光谱数据和理化性质鉴定结构。结果 分离并鉴定了12个化合物的结构， 即甲基-β-芸香糖苷(Ⅰ， 龙胆酸(Ⅱ， 邻苯二酚(Ⅲ， 8-表番木鳖酸(Ⅳ， caryoptoside(Ⅴ， 槲皮素-3-O-β-D-葡萄糖苷(Ⅵ， 山柰酚-3-O-β-芸香糖苷(Ⅶ， 5，4′-二羟基山柰酚-7-O-β-芸香糖苷(Ⅷ， 山柰酚-3-O-β-D-葡萄糖苷(Ⅸ， 1，2，4-苯三酚(Ⅹ， 7-羟基香豆素(Ⅺ， 芦丁(Ⅻ。结论 化合物Ⅰ~Ⅹ为首次从该植物中分离得到。

OBJECTIVE To study the chemical constituents of Hydrangea macrophylla(Thunb. Seringe. METHODS The compounds were isolated and purified by Diaion HP-20， Toyopearl HW-40， and silica gel column chromatography， and their structures were identified on the basis of spectral data and physiochemical properties. RESULTS Twelve compounds were obtained and identified as methyl-β-rutinoside(Ⅰ， gentisic acid(Ⅱ， pyrocatechol(Ⅲ， 8-epiloganic acid(Ⅳ， caryoptoside(Ⅴ， quercetin-3-O-β-D-glucopyranoside(Ⅵ， kaempferol-3-O-β-rutinoside(Ⅶ， 5，4′-dihydroxy-kaempferol-7-O-β-rutinoside(Ⅷ， kaempferol-3-O-β-D-glucopyranoside(Ⅸ， 1，2，4-benzenetri(Ⅹ， 7-hydroxycoumarin(Ⅺ and rutin(Ⅻ. CONCLUSION CompoundsⅠ-Ⅹ were isolated from this plant for the first time.