旋覆花属植物中倍半萜类成分及生物活性的研究进展

张婷 杜冠华 陈若芸

中国药学杂志 ›› 2010, Vol. 45 ›› Issue (24) : 1889-1894.

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中国药学杂志 ›› 2010, Vol. 45 ›› Issue (24) : 1889-1894.
综 述

旋覆花属植物中倍半萜类成分及生物活性的研究进展

  • 张婷,杜冠华,陈若芸*
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摘要

目的 综述近十年来旋覆花属植物的研究进展。 方法 分析和归纳该属植物中的倍半萜类化学成分的结构特点及其药理活性的文献报道。 结果结论 倍半萜类化学成分是菊科旋覆花属植物的特征性成分,以桉叶烷型、吉马烷型和愈创木烷型为主。其药理作用主要集中在细胞毒活性和抗炎两方面。

关键词

旋覆花属 / 倍半萜成分

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张婷 杜冠华 陈若芸 . 旋覆花属植物中倍半萜类成分及生物活性的研究进展[J]. 中国药学杂志, 2010, 45(24): 1889-1894

参考文献


[1] GUO Q L, YANG J S. Sesquiterpenes in Inula L. plants and their pharmacological activities[J]. Nat Prod Res Dev, 2005, 17(6): 804-809.
[2] KONISHI T, SHIMADA Y, NAGAO T, et al. Antiprolferative sesquiterpene lactones from the roots of Inula helenium[J]. Biol Pharm Bull, 2002, 25(10):1370-1372.
[3] YANG C, WANG C M, JIA Z J. Sesquiterpenes and other constituents from the aerial parts of Inula japonica[J]. Planta Med, 2003, 69(7):662-666.
[4] SU B N, TAKAISHI Y, YABUUCHI T, et al. Sesquiterpenes and monoterpenes from the barks of Inula macrophylla[J]. J Nat Prod, 2001, 64(4):466-471.
[5] XIN X L, MA X C, LIN K X, et al. Microbial transformation of alantolactone by Mucor polymorphosporus[J]. J Asian Nat Prod Res, 2008, 10(10):933-937.
[6] FU B, SU B N, TAKAISHI Y, et al. A bis-sesquiterpene and sesquiterpenolides from Inula macrophylla[J]. Phytochemistry, 2001, 58(7):1121-1128.
[7] ZARGA M H, SABRI S S, HAMED E M, et al. A new eudesmane type sesquiterpene from Inula viscosa[J]. Nat Prod Res, 2003, 17(2):99-102.
[8] YANG C, WANG P F, JIA Z J, et al. Two new sesquiterpenes from Inula japonica[J]. Chin Chem Lett(中国化学快报英文版), 2003, 14(5):485-486.
[9] HERNNDEZ V, MNEZ S, RECIO M C, et al. Anti-inflammatory profile of dehydrocostic acid, a novel sesquiterpene acid with a pharmacophoric conjugated diene[J]. Eur J Pharm Sci, 2005, 26(2):162-169.
[10] BAI N S, LAI C S, HE K, et al. Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines[J]. J Nat Prod, 2006, 69(4):531-535.
[11] CHEN Y Z, WEN J K, HAN M, et al. Effects of 1-o-acetylbritannilactone on cyclo-oxygenase-2 and intercellular adhesion molecule-1 expression in human vascular endothelial cells[J]. Chin J Arteriosclerosis, 2005, 13(2):129-132.
[12] HARVALA E, ALIGIANNIS N, SKALTSOUNIS A L, et al. Cytotoxic germacranolides from Inula verbascifolia Subsp. methanea[J]. J Nat Prod, 2002, 65(7):1045-1048.
[13] AHMED A A, MOHAMED A H, TZAKOU O, et al. Terpenes from Inula verbascifolia[J]. Phytochemistry, 2003, 62(8):1191-1194.
[14] CHEN C N, HUANG H H, W U C L, et al. Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells[J]. Cancer Lett, 2007, 246(1/2):237-252.
[15] HERNANDEZ V, RECIO M D C, MANEZ S, et al. A mechanistic approach to the in vivo anti-inflammatory activity of sesquiterpenoid compounds isolated from Inula viscosa[J]. Planta Med, 2001, 67(8):726-731.
[16] MAO M, NEEMAN I. Effects of Inula viscosa extract on chitin synthesis in dermatophytes and Candida albicans[J]. J Ethnopharmacol, 2000, 71(3):479-482.
[17] SU B N, TAKAISHI Y, TORI M, et al. Macrophyllidimers A and B, two novel sesquiterpene dimmers from the bark of Inula macrophylla[J]. Tetrahedron Letters, 2000, 41(7):1475-1479.
[18] SU B N, YOSHIHISA T, MATOO T, et al. Macrophyllols A and B, two unusual novel sesquiterpene and monoterpene dimers from the bark of Inula macrophylla[J]. Org Lett, 2000, 2(4), 483-496.
[19] JIN H Z, LEE D, LEE J H, et al. New sesquiterpene dimers from Inula britannica inhibit NF-κB activivation and NO and TNF-α production in LPS-stimulated RAW264. 7 cells[J]. Planta Med, 2006, 72(1):166-168.
[20] QIN J J, JIN H Z, FU J J, et al. Japonicones A-D, bioactive dimeric sesquiterpenes from Inula japonica thumb[J]. Bio Med Chem Lett, 2009, 19(3):710-713.
[21] QIN J J, JIN H Z, ZHU J X, et al. Japonicones E-L, dimeric sesquiterpene lactones from Inula japonica thumb[J]. Planta Med, 2010, 76(3):278-283.
[22] CAFARCHIA C, DE LAURENTIS N, MILILLO M A, et al. Antifungal activity of essential oils from leaves and flowers of Inula viscosa (Asteraceae) by Apulian region[J]. Parassitologia, 2002, 44(3-4):153-156.
[23] ZHA J P, FUN Y, WU Y B, et al. Study of chemical constituents of the essential oil from Inula britannica L. by GC-MS[J]. J Chin Med, 2005, 28(6):466-468.
[24] STOJAKOWSKA A, KEDZIA B, KISIEL W. Antimierobial activity of 10-isobutyryloxy-8,9-epoxythymol isobutyrate[J]. Fitoterapia, 2005, 76(7-8):687-690.
[25] OZENBLAT S, GROSSMAN S, BERGMAN M, et al. Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines[J]. Biochem Pharmacol, 2008, 75(2):369-382.
[26] RAFI M M, BAI N S, CHI T H, et al. A sesquiterpene lactone from Inula britannica induces anti-tumor effects dependent on Bcl-2 phosphorylation[J]. Anticancer Res, 2005, 25(1A):313-318.
[27] MNEZ S, HERNNDEZ V, GINER R M, et al. Inhibition of pro-inflammatory enzymes by inuviscolide, a sesquiterpene lactone from Inula viscosa[J]. Fitoterapia, 2007, 78(4):329-331.
[28] LEE H T, YANG S W, KIM K H, et al. Pseudoguaianolides isolated from Inula britannia var. chinenis as inhibitory constituents against inducible nitric oxide synthesis[J]. Arch Pharm Res, 2002, 25(2):151-153.
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