摘要
目的对细梗香草全草甲醇部分进行分离和化合物结构鉴定。方法通过大孔树脂纯化,Sephedax LH20和聚酰胺分离;利用多种波谱技术并结合酸水解方法鉴定其化学结构。结果分离鉴定了3个黄酮苷和1个三萜皂苷,分别为槲皮素-3-O-(2,6-α-L-二吡喃鼠李糖基)-β-D-吡喃半乳糖苷(1),capilliposide I(2),capilliposideⅡ(3)和candidoside(4)。结论化合物4为首次从细梗香草中分离得到。
Abstract
OBJECTIVE To study the flavonol glycosides and triterpenoid saponin in the whole plants of Lysimachia capillipes Hemsl.METHODS The column chromatography(including AB-8 macroporous resin,Sephedax LH20 and polyamide) were used to separate constituents whose structures were elucidated by ESI-MS,NMR spectral data and hydrolysis methods.RESULTS Three flavonol glycosides and one triterpenoid saponin were isolated and elucidated as quercetin-3-O-(2,6-di-α-L-rhamnopyranosyl)-β-D-galactopyranoside(1),capilliposide Ⅰ(2),capilliposide Ⅱ(3),and candidoside(4).CONCLUSION Compound 4 was isolated from Lysimachia capillipes for the first time.
关键词
细梗香草 /
capilliposideⅠ /
candidoside
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Key words
Lysimachia capillipes /
candidoside Ⅰ
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田景奎;邹忠梅;徐丽珍;谢忱;杨世林.
细梗香草化学成分的研究[J]. 中国药学杂志, 2006, 41(03): 171-172
TIN Jing-kui;ZOU Zhong-mei;XU Li-zhen;XIE Chen;YNG Shi-lin.
Studies on Chemical Constituents of Lysimachia capillipes[J]. Chinese Pharmaceutical Journal, 2006, 41(03): 171-172
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参考文献
[1] GUO B L，XIAO P G，YANG S L. Progress in studies chemical constituents and pharmacological effect of Lysimachia genus[J] . Foreign Med Sci (Fascicule of Natural Drugs) (国外医药·植物药分册)，1995，10(4)： 159-162.
[2] XIE C，XU L Z，ZHAO B H，et al. Studies on chemical constituents of Lysimachia capillipes[J] .Chin Tradit Herb Drugs(中草药)，2001，32(11)：967-969.
[3] XIE C，XU L Z，LUO X Z，et al. Flavonol glycosides from Lysimachia capillipes[J] .J Asian Nat Prod Res，2002，4：17-23.
[4] TIAN J K，ZOU Z M，XU L Z，et al. Two new saponins from Lysimachia capillipes[J] .Acta Pharm Sin(药学学报)，2004，39(9)：722-725.
[5] ZHANG X R，PENG S L，XIAO S C，et al. Saponins from Lysimachia candida[J] .Acta Bota Sin，1999，41(5)：534-536.
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脚注
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基金
国家自然科学基金资助项目(39870085)
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