OBJECTIVE To prepare oxymatrine sustained-release tablets and evaluate the drag release property.METHODS Oxyma-trine sustained-release tablets were prepared with HPMC by wetting granulating method. The release rates of the sustained-release tablets were determined and the effects of the release medium were investigated. RESULTS The prepared sustained-release tablets had an obvious sustained-release effect, and the drug release pattern folloloed the first order kinetics[ln(100- Q) =- 0.11t+4.50,r = 0.9998].CONCLUSION The sustained-release tablets reach the expectable results with its reasonable formulation and simple technology.
WN F-li;DENG Shu-hi;MIO Ci-yun.
Sutdy on preparation and in vitro release of oxymatrine sustained-release tablets [J]. Chinese Pharmaceutical Journal, 2005, 40(13): 1002-1003
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