目的 评价非那雄胺国产片剂和进口片剂在人体内生物等效性。方法 采用高效液相色谱紫外检测法测定20名健康受试者单剂量po10 mg非那雄胺国产或进口片剂后，血浆中非那雄胺的浓度。结果 非那雄胺国产片剂和进口片剂的AUC_0~24均值分别为（840.63±140.84)和（847.51±166.96)ng·h·mL^-1实测c_max均值分别为（117.17±19.74)和（117.43±18.06)ng·mL^-1,实测t_{max分别为（1.88 ±0.48)和（1.95±0.43)h,国产非那雄胺片剂的相对生物利用度为（100.73±15.27)%。结论 经统计学分析,供试制剂和参比制剂具有生物等效性。}

OBJECTIVE To evaluate the bioequivalence of domestic finasteride tablet and imported tablet. METHODS A single oral dose of 10 mg domestic tablet or imported tablet was given to 20 healthy volunteers in a randomized crossover study. The concentrations of finasteride were determined by HPLC method. RESULTS The main pharmacokinetic parameters of the two products were as follows：AUQ_0-24(840.63±140.84) and (847.51±166.96) ng-h-mL^-1, c_max(117.17±19.74) and (117.43±18.06) ng·mL^-1, t_max(1.88±0.48) and (1.95±0.43)h，respectively. The relative bioavailability of domestic tablet to imported tablet was (100.73土15.27)%. There were no significant differences on the pharmacokinetic parameters between the two preparations(P>0.05). CONCLUSION The results demonstrated that the two preparations were bioequivalent.