生物熵在药物研究中的应用

郭慧慧, 高天乐, 马晓蕾, 铁偲, 蒋建东

中国药学杂志 ›› 2025, Vol. 60 ›› Issue (3) : 209-213.

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中国药学杂志
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中国药学杂志 ›› 2025, Vol. 60 ›› Issue (3) : 209-213. DOI: 10.11669/cpj.2025.03.001
综述

生物熵在药物研究中的应用

  • 郭慧慧1, 高天乐1, 马晓蕾1, 铁偲2, 蒋建东1,3*
作者信息 +

Application of Bio-entropy in Drug Evaluation

  • GUO Huihui1, GAO Tianle1, MA Xiaolei1, TIE Cai2, JIANG Jiandong1,3*
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文章历史 +

摘要

熵是一个源于物理学的概念,表示物质紊乱的程度。熵增定律是揭示事物消亡的自然规律。在生物学领域,也可用熵来度量生命活动过程中的质量,一般来说,生物熵越低越好。生命体依赖其自组织、防御、自愈、抗磨损和适应等负熵能力来对抗熵增,从而逆转疾病抵抗衰老,保持健康。而药物治疗的实质是作为外部干预的力量,通过增强以上某种或几种能力,产生负熵效应,协助机体恢复至有序状态。笔者探讨了生物熵在药物研究中的应用,期望未来能够利用生物熵更正确地认识药物靶点、解释药物作用机制、设计新药以及科学地评估药物(包括中药)的疗效及安全性。

Abstract

The concept of entropy is originated from physics which represents a degree of disorder. Entropy increase is a natural law for extinction of things. In the field of life science, entropy could be used to measure the quality of life. Organisms utilize their inherent negative entropy mechanisms of self-organization, defense, self-healing, wear resistance, and adaptability to counteract entropy increase, and thus to cure various diseases and curb aging processes, while maintaining optimal health. As an external intervention, good drugs could trigger negative entropy mechanisms by enhancing one or more of the above machineries, thus assist the body to recover. This article explores the potential applications of biological entropy in drug discovery research, aiming to leverage its power in the future for a good understanding of drug targets, elucidation of drug mechanisms, rational design of novel drugs and rigorous evaluation of drug efficacy, especially pertinent to multi-target drugs.

关键词

生物熵 / 高度有序 / 生理信号熵 / 中药 / 药效评价

Key words

bio-entropy / highly ordered structure / physiological signal entropy / traditional Chinese medicine / efficacy evaluation

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导出引用
郭慧慧 , 高天乐 , 马晓蕾 , 铁偲 , 蒋建东. 生物熵在药物研究中的应用[J]. 中国药学杂志, 2025, 60(3): 209-213 https://doi.org/10.11669/cpj.2025.03.001
GUO Huihui , GAO Tianle , MA Xiaolei , TIE Cai , JIANG Jiandong. Application of Bio-entropy in Drug Evaluation[J]. Chinese Pharmaceutical Journal, 2025, 60(3): 209-213 https://doi.org/10.11669/cpj.2025.03.001
中图分类号： R966   

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基金

国家自然科学基金项目资助(82104254,82374061);中国工程院战略研究与咨询项目资助(2023-XZ-88)
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