1.Key Laboratory of Marine Drugs of MEC��School of Medicine and Pharmacy��Ocean University of China��Qingdao 266003��China�� 2.School of Chemical Engineering��Qingdao University of Science and Technology��Qingdao 266042��China
Abstract��
OBJECTIVE To investigate the cytotoxic secondary metabolites of marine-derived fungus Aspergillus sydowi PFW-13.METHODS Active compounds were isolated with bioassay-guided separation procedure and their structures were identified by means of spectral analysis and physicochemical properties.Their anti-tumor activities were preliminarily evaluated in vitro by the SRB method.RESULTS Six quinazoline alkaloids including a new natural product(6) were isolated and their structures were identified as fumiquinazolines A(1),fumiquinazolines C(2),fumiquinazolines D(3),fumiquinazolines F(4),fumiquinazolines G(5),fumiquinazolines J(6),respectively.Compound 2 and 6 showed cytotoxicity against tsFT210,A549,BEL-7402,HL60 and P388 cells with the IC50 values in the range of 1��10-5��1��10-4 mol��L-1.CONCLUSION All these compounds were obtained from this fungus for the first time.
.Study on Indole-Quinazolines Alkaloids from Marine-Derived Fungus Aspergillus sydowi PFW-13 and their Anti-Tumor Activities [J] Chinese Pharmaceutical Journal, 2007,V42(24): 1848-1851
2007, Vol. 42 