Abstract：OBJECTIVE To analyze the cases of severe hypertriglyceridemia caused by capecitabine reported in literature and found in our hospital, so as to understand the characteristics, prevention and intervention measures of this adverse reaction. METHODS Case reports of severe hypertriglyceridemia(HTG)caused by capecitabine were retrieved from PubMed and CMKI website database, and relevant information, such as patients′ basic information, capecitabine medication, triglyceride(TG)level,chronic disease,complication, lipid-lowering treatment, was extracted. Microsoft Excel 2013 was used to analyze the data. RESULTS Twenty-one cases of severe HTG(TG≥500 mg·dL-1) caused by capecitabine were reported in 14 literatures. A total of 23 cases were included in the analysis, including 2 cases found in our hospital. Among them, there were 10 males and 13 females. The mean age is (57.6±8.8)years. The TG level of 18 patients was grade 4, and that of 5 patients was grade 3. Twelve patients had basic diseases such as dyslipidemia, abnormal blood glucose or obesity; thirteen patients with hyperlipidemia were complicated with hypercholesterolemia, hyperglycemia or acute pancreatitis. Sixteen patients were treated with lipid-lowering drugs, including fibrates, statins and omega-3 fatty acids. After drug treatment, drug withdrawal and other interventions, the TG level of 19 patients decreased to below grade 2. CONCLUSION In clinical practice, attention should be paid to the effect of capecitabine on blood lipid metabolism, and the occurrence of severe hyperlipidemia should be vigilant. During capecitabine treatment, for patient with dyslipidemia, diabetes, obesity and other metabolic diseases, as well as menopausal women, blood lipid monitoring should be done to ensure the safety of patients.
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