Preparation and Evaluation of Amphiphilic Curcumin-Polyethylene Glycol-Grafted Chitosan Coupled with Deoxycholic Acid Micelles
LU Xiao-feng1, DAI Ying-ying1, SHEN Ming-feng1, LIU Yang2, HU Xiao-bo1*
1. Department of Pharmacy, Suzhou Ninth People′s Hospital, Suzhou 215200, China; 2. College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China
Abstract：OBJECTIVE To synthesize the polyethylene glycol(mPEG)-grafted chitosan coupled with deoxycholic acid, and to prepare the curcumin-loaded micelles and characterize their physicochemical properties. METHODS mPEG-chitosan-deoxycholic acid was synthesized by two steps, and its structure was characterized by IR, 1H NMR and the physical properties were charaterized by differential scanning calorimetry(DSC).The solubility of carrier was investigated in various solvents, and the solubilization capacity for insoluble drugs was also discussed.The preparation method of mPEG-CS-DA-Cur micelles was optimized, and the entrapment efficiency, drug loading, particle size distribution and drug release behavior were also characterized. RESULTS The drug-loaded nano-micelles prepared by dialysis method have the characteristics of high entrapment efficiency, small average particle size and no residual solvent,the drug loading of mPEG-CS-DA-Cur micelles was(12.11±1.52)%, the encapsulation efficiency was(89.37±4.12)%, and the average particle size was 161.4nm with uniform distribution .The drug release from the micelles was relativley slow and stable. CONCLUSION A new type of chitosan derivative with amphiphilic charateristics is synthesized in this study,and it will be an excellent micelle carriers. It shows high encapsulation efficiency and drug loading for curcumin,which provides a certain references for the follow-up drug targeting research.
陆肖枫, 戴盈英, 沈明丰, 刘扬, 胡晓波. 两亲性纳米胶束聚乙二醇接枝壳聚糖偶联脱氧胆酸-姜黄素的制备与评价[J]. 中国药学杂志, 2022, 57(19): 1660-1665.
LU Xiao-feng, DAI Ying-ying, SHEN Ming-feng, LIU Yang, HU Xiao-bo. Preparation and Evaluation of Amphiphilic Curcumin-Polyethylene Glycol-Grafted Chitosan Coupled with Deoxycholic Acid Micelles. Chinese Pharmaceutical Journal, 2022, 57(19): 1660-1665.
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2022, Vol. 57 
