Effect of Actuator on Spray Plume Characteristics and in Vitro Deposition of Pressurized Metered Dose Inhalers
YIN Xiao-qing1, CHEN Lan1,2, SHAO Qi3*
1. School of Health Science and Engineering, University of Shanghai for Science and Technology,Shanghai 200093, China; 2. Hangzhou Chance Pharmaceuticals Co., Ltd., Hangzhou 311121, China; 3. Shanghai Sine Pharmaceutical Lab. Co., Ltd., Shanghai 201206, China
Abstract：OBJECTIVE To investigate the effect of actuator orifice diameter and orifice length on spray plume characteristics and the in vitro deposition of pressurized metered dose inhalers. METHODS Salbutamol sulphate inhalationaerosol was selected as the model drug. The two-factors and three-levels analysis of variance, and response surface analysis are adopted to analyze the plume geometry, speed and aerodynamic particle size distribution. RESULTS When the orifice length increased,the spray angle and key quality attributes associated with deposition decreased, however delivery rate, spray speed and the ratio of drug deposited at the throat device increased significantly(P<0.05). When the orifice diameter increased, the spray speed and the ratio of drug deposited at the throat device increased, but particle distribution parameters reduced. CONCLUSION The change of spray angle, spray speed and plume time caused by the alteration of orifice diameter and orifice length will lead to the change of aerodynamic particle size distribution. It is recommended that actuator parameters should been given priority in order to improve product screening efficiency.
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2022, Vol. 57 
