Abstract：How to overcome the problem of drug resistance to tumors caused by the loss or obstruction of tumor cell apoptosis is one of the urgent problems to be solved in cancer treatment. It could be a new strategy for cancer treatment to discover a new programmed cell death of non-apoptosis and utilize the corresponding drugs with action mechanism described above. Paraptosis is a kind of new programmed cell death, which is usually accompanied by cytoplasmic vacuolation derived from endoplasmic reticulum stress, proteasome inhibition or ion homeostasis imbalance, and which is caspase independent. The current review outlined the mechanism of cell paraptosis and the compounds that induce cell paraptosis. Then, the trend in this field was discussed to offer a new idea for cancer treatment.
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