Research Progress in the Synthesis and Biological Activity of Phenothiazines
TIAN Shi-yi1, FANG Fang1,2*
1. College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; 2. Department of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei 230012, China
Abstract：Phenothiazine is a hetero-atomic tricyclic derivative, which was first discovered and applied in the dye industry in the second half of the 19th century. In recent years, some derivatives with phenothiazine structure as parent nucleus have been found to have a variety of pharmacological activities, such as anti-cancer, antibacterial,anti-Alzheimer, anti-oxidation and anti-virus activities. In order to provide reference for the in-depth systematic research of phenothiazine compounds, this article reviews the research progress in the synthesis of phenothiazine compounds and their related biological activities, and the structure-activity relationship of phenothiazine derivatives with different activity types is summarized.
田诗意, 方方. 吩噻嗪类化合物的合成及其生物活性研究进展[J]. 中国药学杂志, 2022, 57(18): 1504-1511.
TIAN Shi-yi, FANG Fang. Research Progress in the Synthesis and Biological Activity of Phenothiazines. Chinese Pharmaceutical Journal, 2022, 57(18): 1504-1511.
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