Clinical Features and Risk Factors of Coagulation Disorders Caused by Cefoperazone Sodium and Sulbactam Sodium
ZHU Yuan-chao1, LIANG Liang2, SHEN Ji2, CHEN Di1, HU Xin1*
1. Department of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Assessment of Clinical Drugs Risk and Individual Application, Beijing 100730; 2. Department of Geriatric Medicine, Beijing Hospital, Beijing 100730, China
Abstract：OBJECTIVE To find the clinical characteristics and risk factors of coagulation disorders induced by cefoperazone sodium and sulbactam sodium, and provide a basis for rational use of cefoperazone sodium and sulbactam sodium. METHODS A retrospective study was conducted on patients who received cefoperazone sodium and sulbactam sodium from January 2013 to December 2019. The whole therapeutic process was recorded. RESULTS A total of unique 3 259 patients were enrolled in this study, 136 patients experienced coagulation disorder. Coagulation disorders developed 3-15 days after medication, with an average of (6.59±3.24) days, 99.3% (135/136) of the patients had Grade 1-3 adverse reactions. Multivariate logistic regression analysis showed that dose ≥ 95 mg·kg-1, treatment course ≥ 9 days, liver and kidney dysfunction and food intake deficiency were the independent risk factors for coagulation disorders caused by cefoperazone sodium and sulbactam sodium (P<0.05). CONCLUSION Cefoperazone sodium and sulbactam sodium can cause coagulation disorders, and the incidence of moderate adverse reactions is high. For patients underlying more than two risk factors, it is recommended to use vitamin K prophylacticly or choose other antibiotics with less impact on coagulation function.
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