Effect of Gastrointestinal Mucus on Transmembrane Drug Delivery and the Research Progress of Oral Drug Delivery Strategies
LIU Huan1, LIANG Xin-Li1, JIANG Qie-ying2*, CHEN Xu-long1, LIAO Zheng-gen1*
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China; 2. Laboratory Animal Science and Technology Center, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Abstract：The gastrointestinal mucus is the primary barrier of the gastrointestinal transport barrier,which can prevent particles and drug molecules from penetrating to the epithelial cells of the mucosal tissue. For oral drug delivery, the gastrointestinal mucus is the first barrier that the drug must overcome. For macromolecular drugs such as proteins and peptides, the meshes larger than the mucus cannot penetrate the mucus layer; some have physical and chemical interactions with the mucus. The small molecule drugs are trapped in the mucus layer and cannot achieve rapid penetration; the drugs carried away by the continuously secreted and cleared mucus also cannot effectively penetrate the mucus layer.Therefore,achieving rapid and effective mucus penetration is of great significance to drug absorption. This article systematically reviews the composition and structure of mucus,the physicochemical properties of mucus, the barrier properties of mucus,and the drug delivery system that improves mucus penetration,in order to provide theoretical guidance for the study of improving the mucus permeability of drugs.
刘欢, 梁新丽, 蒋且英, 陈绪龙, 廖正根. 胃肠道黏液对跨膜转运药物的影响及口服药物传递策略研究进展[J]. 中国药学杂志, 2022, 57(3): 176-180.
LIU Huan, LIANG Xin-Li, JIANG Qie-ying, CHEN Xu-long, LIAO Zheng-gen. Effect of Gastrointestinal Mucus on Transmembrane Drug Delivery and the Research Progress of Oral Drug Delivery Strategies. Chinese Pharmaceutical Journal, 2022, 57(3): 176-180.
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