胃肠道黏液对跨膜转运药物的影响及口服药物传递策略研究进展

刘欢, 梁新丽, 蒋且英, 陈绪龙, 廖正根

中国药学杂志 ›› 2022, Vol. 57 ›› Issue (3) : 176-180.

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中国药学杂志
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中国药学杂志 ›› 2022, Vol. 57 ›› Issue (3) : 176-180. DOI: 10.11669/cpj.2022.03.003
综述

胃肠道黏液对跨膜转运药物的影响及口服药物传递策略研究进展

  • 刘欢1, 梁新丽1, 蒋且英2*, 陈绪龙1, 廖正根1*
作者信息 +

Effect of Gastrointestinal Mucus on Transmembrane Drug Delivery and the Research Progress of Oral Drug Delivery Strategies

  • LIU Huan1, LIANG Xin-Li1, JIANG Qie-ying2*, CHEN Xu-long1, LIAO Zheng-gen1*
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文章历史 +

摘要

胃肠道黏液是胃肠道转运屏障的首要屏障,可阻碍颗粒和药物分子渗透至黏膜组织上皮细胞。对于口服药物的递送,胃肠道黏液是药物必须克服的第一道屏障,蛋白质、多肽等大分子药物,其尺寸大于黏液的网孔无法穿透黏液层。一些与黏液发生物理化学相互作用的小分子药物被困于黏液层中,无法实现快速渗透;被不断分泌和清除的黏液带走的药物同样无法有效的穿透黏液层。因此实现快速有效的黏液渗透对药物的吸收有着重要的意义。本研究对黏液组成与结构、黏液的物理化学性质、黏液的屏障特性以及改善黏液渗透的药物递送系统进行系统的综述,以期为提高药物的黏液渗透性研究提供理论指导。

Abstract

The gastrointestinal mucus is the primary barrier of the gastrointestinal transport barrier,which can prevent particles and drug molecules from penetrating to the epithelial cells of the mucosal tissue. For oral drug delivery, the gastrointestinal mucus is the first barrier that the drug must overcome. For macromolecular drugs such as proteins and peptides, the meshes larger than the mucus cannot penetrate the mucus layer; some have physical and chemical interactions with the mucus. The small molecule drugs are trapped in the mucus layer and cannot achieve rapid penetration; the drugs carried away by the continuously secreted and cleared mucus also cannot effectively penetrate the mucus layer.Therefore,achieving rapid and effective mucus penetration is of great significance to drug absorption. This article systematically reviews the composition and structure of mucus,the physicochemical properties of mucus, the barrier properties of mucus,and the drug delivery system that improves mucus penetration,in order to provide theoretical guidance for the study of improving the mucus permeability of drugs.

关键词

黏液屏障 / 口服药物 / 渗透 / 药物递送系统

Key words

mucus barrier / oral medication / penetration / drug delivery system

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刘欢, 梁新丽, 蒋且英, 陈绪龙, 廖正根. 胃肠道黏液对跨膜转运药物的影响及口服药物传递策略研究进展[J]. 中国药学杂志, 2022, 57(3): 176-180 https://doi.org/10.11669/cpj.2022.03.003
LIU Huan, LIANG Xin-Li, JIANG Qie-ying, CHEN Xu-long, LIAO Zheng-gen. Effect of Gastrointestinal Mucus on Transmembrane Drug Delivery and the Research Progress of Oral Drug Delivery Strategies[J]. Chinese Pharmaceutical Journal, 2022, 57(3): 176-180 https://doi.org/10.11669/cpj.2022.03.003
中图分类号： R944   

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江西省一流学科项目资助(JXSYLXK-ZHYAO059)
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