非酒精性脂肪性肝病中微小RNA调控肝脂肪变性机制的研究进展

郭帅帅, 马艺溢, 肇丽梅

中国药学杂志 ›› 2022, Vol. 57 ›› Issue (2) : 90-95.

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中国药学杂志
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中国药学杂志 ›› 2022, Vol. 57 ›› Issue (2) : 90-95. DOI: 10.11669/cpj.2022.02.002
综述

非酒精性脂肪性肝病中微小RNA调控肝脂肪变性机制的研究进展

  • 郭帅帅, 马艺溢, 肇丽梅*
作者信息 +

The Mechanism of MicroRNA Regulation of Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease

  • GUO Shuai-shuai, MA Yi-yi, ZHAO Li-mei*
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文章历史 +

摘要

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)与机体细胞内脂质代谢的紊乱有关,即肝细胞中脂质获取与去除之间的不平衡导致细胞质中甘油三酯(triglyceride,TG)的聚积。微小RNA(miRNA)是1类长度约为22个核苷酸片段的非编码小分子RNA,在转录后水平通过翻译抑制或降解/裂解mRNA两种方式来调控基因的表达。越来越多的证据表明,miRNAs与NAFLD的发生、发展密切相关,并且miRNAs广泛参与调控脂质合成、代谢相关靶基因表达的过程。笔者从miRNAs调控脂质代谢通路的角度总结了有关NAFLD中miRNAs调控肝脂肪变性的机制,并简要分析了miRNAs作为NAFLD的生物标志物和/或治疗靶点的潜在用途。

Abstract

Non-alcoholic fatty liver disease (NAFLD) is associated with the disturbance of lipid metabolism in the body cells, that is, the imbalance between lipid acquisition and removal in liver cells leads to the accumulation of triglycerides (TG) in the cytoplasm. MicroRNAs (miRNAs) are a class of small non-coding RNAs with a length of about 22 nucleotide fragments, which regulate gene expression at the post-transcriptional level through either translation inhibition or degradation/cleavage of mRNA. More and more evidences show that miRNAs are closely related to the occurrence and development of NAFLD, and miRNAs are widely involved in lipid synthesis and metabolism. In this review, the mechanism of miRNAs regulating hepatic steatosis in NAFLD from the perspective of the regulation of lipid metabolism pathways by miRNAs were investigated and summarized, and the potential use of miRNAs as biomarkers and/or therapeutic targets for NAFLD was briefly analyzed.

关键词

非酒精性脂肪性肝病 / 微小RNA / 脂质代谢

Key words

non-alcoholic fatty liver disease / microRNA / lipid metabolism

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导出引用
郭帅帅, 马艺溢, 肇丽梅. 非酒精性脂肪性肝病中微小RNA调控肝脂肪变性机制的研究进展[J]. 中国药学杂志, 2022, 57(2): 90-95 https://doi.org/10.11669/cpj.2022.02.002
GUO Shuai-shuai, MA Yi-yi, ZHAO Li-mei. The Mechanism of MicroRNA Regulation of Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease[J]. Chinese Pharmaceutical Journal, 2022, 57(2): 90-95 https://doi.org/10.11669/cpj.2022.02.002
中图分类号： R966   

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基金

国家自然科学基金项目资助(82073936)
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