Research Progress of Cell Membrane Coated Nanoscale Drug Delivery System in Tumor Therapy
LI Ai-xue1,2, ZHAO Yu-nan2, JIANG Liang-di1,2, GU Yong-wei2, LIU Ji-yong2*
1. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China; 2. Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai 200032, China
Abstract：Nanotechnology provides new delivery carriers for tumor drug therapy to increase the stability and solubility of drugs, prolong their half-life and improve the efficacy. However, the traditional nano-delivery system based on synthetic materials has poor targeting and potential systemic toxicity, and is easy to be cleared by the immune system. Cell membrane coated nanoscale drug delivery system has become a research hotspot in pharmaceutics because of its advantages such as high drug loading, active targeting and good biocompatibility. In addition, the functions of cell membranes are different according to their source. Therefore, red blood cell membranes, immune cell membranes, platelet membranes and tumor cell membranes can be loaded or coated with nanoparticles based on different treatment targets. This article mainly reviews the research status of different types of biomimetic nano-drug delivery systems coated with cell membrane in tumor therapy, as well as the challenges and development prospects in clinical application.
李爱雪, 赵语南, 姜良弟, 顾永卫, 刘继勇. 细胞膜包载的纳米递药系统在肿瘤治疗中的研究进展[J]. 中国药学杂志, 2022, 57(1): 1-7.
LI Ai-xue, ZHAO Yu-nan, JIANG Liang-di, GU Yong-wei, LIU Ji-yong. Research Progress of Cell Membrane Coated Nanoscale Drug Delivery System in Tumor Therapy. Chinese Pharmaceutical Journal, 2022, 57(1): 1-7.
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