Abstract：OBJECTIVE To construct a temperature sensitivegel nanoparticle nasal drug deliverysystem and improve the shortcomings of exenatide (EX) injection, such as poor stability, short half life in vivo, and poor patient compliance. METHODS Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were combined with poloxamer temperature-sensitive gel, and EX was coated with polydopamine (PDA) peptide (PLGA) nanoparticles and prepared into temperature-sensitive gel (EX-NPS-GEL). The morphology, drug loading, phase transition temperature, rheology, and drug release of EX-NPS-GEL were investigated, and hypoglycemic test, blood drug concentration test and nasal mucosal irritation test were carried out in type 2 diabetes balb/c model mice. RESULTS EX-NPS-GEL can be retained in the nasal mucosa for a long time, effectively prolonging the time of lowering blood sugar in the animal body and increasing the blood drug concentration. CONCLUSION It provides a new way of administration for the treatment of diabetes, improves the effect of drugs, relieves the pain of patients with medication, and provides certain inspiration and support for the development of protein peptide drugs for nasal delivery.
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2021, Vol. 56 
