恶性肿瘤已经成为全球死亡的主要原因之一,探索有效的抗肿瘤治疗新方法一直是肿瘤研究的热点。超声微泡(USMB)载药系统作为一种非侵入性的、靶向性的肿瘤治疗新方法,近年来引起了人们的广泛关注。微泡由带有稳定壳层的气腔组成,并且可负载各种抗肿瘤药,在超声辐射的作用下就能穿透体内各种生理屏障及高异质性的肿瘤组织,再通过空化效应使载药微泡炸裂,定点释放药物,另外载药微泡还具有保护药物免受降解以及降低药物副作用等优点。因此超声微泡介导的载药系统可以完美的解决抗肿瘤药物在治疗过程中存在的半衰期短、易产生耐药性以及对人体的有害副作用等一系列问题。本文通过收集整理近年来USMB抗肿瘤治疗的文献,对于USMB介导抗肿瘤靶向治疗进行综述,为肿瘤患者的临床治疗提供了新思路。
Abstract
Malignant tumor has become one of the main causes of death in the world, and exploring effective new methods of anti-tumor therapy has always been the focus of tumor research. Ultrasonic microbubble (USMB) drug delivery system, as a new non-invasive and targeted method for tumor therapy, has attracted wide attention in recent years. Microbubbles are composed of air cavities with a stable shell and can be loaded with various antineoplastic drugs. Under the action of ultrasonic radiation, microbubbles can penetrate various physiological barriers and highly heterogeneous tumor tissues in the body, and then burst drug-loaded microbubbles through cavitation effect to release drugs at a fixed point. In addition, drug-loaded microbubbles also have the advantages of protecting drugs from degradation and reducing drug side effects. So the ultrasound microbubble-mediated drug loading system can perfectly resolve a series of problems such as short half-life, drug resistance and harmful side effects of antineoplastic drugs in the treatment process. Therefore, by collecting and collating the literature of USMB anti-tumor therapy in recent years, this paper reviews the anti-tumor targeted therapy mediated by USMB.
关键词
超声微泡 /
载药系统 /
抗肿瘤药 /
靶向治疗 /
肿瘤
{{custom_keyword}} /
Key words
ultrasonic microbubble /
drug loading system /
antineoplastic drug /
targeted therapy /
tumor
{{custom_keyword}} /
中图分类号：
R730.58
{{custom_clc.code}}
({{custom_clc.text}})
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] ZHANG Q, LI L. Photodynamic combinational therapy in cancer treatment[J]. J B. u. on, 2018, 23(3): 561-567.
[2] AMBIKA R M. Ultrasound-guided microbubble in the treatment of cancer: A mini narrative review[J]. Cureus, 2018, 10(9): e3256.
[3] INGRAM N, MCVEIGH L E, ABOU-SALEH R H, et al. Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues[J]. Theranostics, 2020, 10(24): 10973-10992.
[4] LUO M H, YEH C K, SITU B, et al. Microbubbles: A novel strategy for chemotherapy[J]. Curr Pharm Des, 2017, 23(23): 3383-3390.
[5] WANG S, HOSSACK J A, KLIBANOV A L. From anatomy to functional and molecular biomarker imaging and therapy: ultrasound is safe, ultrafast, portable, and inexpensive[J]. Invest Radiol, 2020, 55(9): 559-572.
[6] CHOWDHURY S M, ABOU-ELKACEM L, LEE T, et al. Ultrasound and microbubble mediated therapeutic delivery: Underlying mechanisms and future outlook[J]. J Controlled Release, 2020, 326: 75-90.
[7] GONG Q, GAO X, LIU W, et al. Drug-loaded microbubbles combined with ultrasound for thrombolysis and malignant tumor therapy[J]. Biomed Res Int, 2019, 2019: 6792465.
[8] FAN C H, CHENG Y H, TING C Y, et al. Ultrasound/magnetic targeting with SPIO-DOX-microbubble complex for image-guided drug delivery in brain Tumors[J]. Theranostics, 2016, 6(10): 1542-1556.
[9] CAI X, JIANG Y, LIN M, et al. Ultrasound-responsive materials for drug/gene delivery[J]. Front Pharmacol, 2019, 10: 1650.
[10] CHOWDHURY S M, LEE T, BACHAWAL S V, et al. Longitudinal assessment of ultrasound-guided complementary microRNA therapy of hepatocellular carcinoma[J]. J Controlled Release, 2018, 281: 19-28.
[11] MIGNET N, MARIE C, DELALANDE A, et al. Microbubbles for nucleic acid delivery in liver using mild sonoporation[J]. Methods Mol Biol, 2019, 1943: 377-387.
[12] ENDO-TAKAHASHI Y, MARUYAMA K, NEGISHI Y. Nucleic acid delivery system by the combination of lipid bubbles and ultrasound[J]. Curr Pharm Des, 2018, 24(23): 2673-2677.
[13] MULLICK C S, LEE T, WILLMANN J K. Ultrasound-guided drug delivery in cancer[J]. Ultrasonography, 2017, 36(3): 171-184.
[14] CAO Y, CHEN Y, YU T, et al. Drug release from phase-changeable nanodroplets triggered by low-intensity focused ultrasound[J]. Theranostics, 2018, 8(5): 1327-1339.
[15] HOU R, LIANG X, LI X, et al. In situ conversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy[J]. Biomater Sci, 2020, 8(9): 2526-2536.
[16] PI Z, HUANG Y, SHEN Y, et al. Sonodynamic therapy on intracranial glioblastoma xenografts using sinoporphyrin sodium delivered by ultrasound with microbubbles[J]. Ann Biomed Eng, 2019, 47(2): 549-562.
[17] ZHENG S, SONG D, JIN X, et al. Targeted microbubbles with ultrasound irradiation and PD-1 inhibitor to increase antitumor activity in B-cell lymphoma[J]. Nanomedicine (Lond), 2018, 13(3): 297-311.
[18] LI T, HU Z, WANG C, et al. PD-L1-targeted microbubbles loaded with docetaxel produce a synergistic effect for the treatment of lung cancer under ultrasound irradiation[J]. Biomater Sci, 2020, 8(5): 1418-1430.
[19] MA Y, HAN J, JIANG J, et al. Ultrasound targeting of microbubble-bound anti PD-L1 mAb to enhance anti-tumor effect of cisplatin in cervical cancer xenografts treatment[J]. Life Sci, 2020, 262: 118565.
[20] QIN Y E, TANG W F, XU Y, et al. Ultrasound-mediated co-delivery of miR-34a and sPD-1 complexed with microbubbles for synergistic cancer therapy[J]. Cancer Manag Res, 2020, 12: 2459-2469.
[21] LIUFU C, LI Y, LIN Y, et al. Synergistic ultrasonic biophysical effect-responsive nanoparticles for enhanced gene delivery to ovarian cancer stem cells[J]. Drug Deliv, 2020, 27(1): 1018-1033.
[22] QIAN X, WANG Y, XU Y, et al. Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y1 receptor-overexpressed breast cancer[J]. J Mater Chem B, 2020, 8(31): 6837-6844
[23] WANG C J, WANG H Z, LI W. A novel conjunction of folate-targeted carbon nanotubes containing protohemin and oridonin-liposome loaded microbubbles for cancer chemo-sonodynamic therapy[J]. J Drug Target, 2019, 27(10): 1076-1083.
[24] ZHAO X Z, ZHANG W, CAO Y, et al. A cleverly designed novel lipid nanosystem: targeted retention, controlled visual drug release, and cascade amplification therapy for mammary carcinoma in vitro[J]. Int J Nanomed, 2020, 15: 3953-3964.
[25] LI T, HU Z, WANG C, et al. PD-L1-targeted microbubbles loaded with docetaxel produce a synergistic effect for the treatment of lung cancer under ultrasound irradiation[J]. Biomater Sci, 2020, 8(5): 1418-1430.
[26] MAO C Q, DU J Z, SUN T M, et al. A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy[J]. Biomaterials, 2011, 32(11): 3124-3133.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
基金
国家自然科学基金项目资助(81673675)
{{custom_fund}}
PDF(1036 KB)
