Abstract：OBJECTIVE To shorten preparation time of drug nanocrystals and reduce drug consumption. METHODS In this experiment, the optimal stabilizers of meloxicam,indomethacin, clotrimazole and glibenclamide were screened by miniature high-throughput technology, and the average particle size and physical stability were analyzed to explore the feasibility and advantages of miniature high-throughput technology in screening drug nanocrystals′ stabilizers.RESULTS It is found that the screening of drug nanocrystal stabilizers by miniature high-throughput technology reduces the drug consumption and shortens the screening time compared with conventional experimental methods. CONCLUSION It has comparable results with the scale-up preparation, which has good application.
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2021, Vol. 56 
