Preparation of Highly Transparency Hydromellose Plant Capsules
ZHANG Na1, LI Ai-xiang1*, LI Zhi-qiang2,WANG Lei2
1. School of Material Science and Engineering, Shandong University of Technology, Zibo 255049, China; 2. Shandong Healsee Capsule Co., Ltd., Zibo 255000, China
Abstract：OBJECTIVE To prepare high-transparency HPMC hollow capsules by using hypromellose (HPMC) as the main material, adding gel, coagulant and plasticizer, and changing the formulation and process. METHODS By optimizing the amount of cold gel, potassium salt, additive and curing temperature, aging time, drying method and drying temperature, the most suitable formula and preparation parameters of high transparency HPMC plant capsules were optimized. RESULTS The optimal formulation and process for preparing high-transparency HPMC plant capsules were as follows:1 000 parts of HPMC, 13 parts of gellan gum, 10.5 parts of potassium citrate, 5 parts of polyvinyl alcohol, 1.2 parts of triethyl citrate, 4 500 parts of distilled water, and homogenization 5 200 r·min-1 for 2 min,aging at 87 ℃ for 1-2 h, after dipping in the glue and cooling at 10 ℃ for 45-50 min, drying at 40 ℃. CONCLUSION The results show that the greatest impact factor on product transparency is the capsule drying mode and temperature.After dipping in the glue, the preserve in the low temperature environment can promote the dissolution of HPMC in the wet capsule, which can effectively improve the transparency of the capsule.
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2020, Vol. 55 
