Abstract：OBJECTIVE To understand the current situation of off-indication drug use of folic acid in our hospital, to explore the rationality of the use of folic acid in combination with the latest guidelines, Meta-analysis and other data, to put forward suggestions for improvement and to provide reference for the rational use of folic acid in clinic. METHODSE Retrospective study method was used to select all outpatient prescriptions of folic acid in our hospital from January 2019 to October 2019. According to the “drug instructions”,relevant guidelines and consensus of experts,the data were processed and analyzed by Excel software. RESULTS A total of 12 087 patients were included, including 11 226 patients using 5 mg folic acid and 861 patients using 0.4 mg folic acid.The results showed that there were 18 departments using 5 mg folic acid. The diagnosis of folic acid was found in nervous system, immune system and kidney system. Sixteen departments, including obstetrics, family planning, gynecology and respiratory medicine, used 0.4 mg folic acid, which were mainly diagnosed as pregnancy examination, infertility, menopause, postoperative lung cancer and so on. CONCLUSION At present,there is a universal phenomenon of off-indication drug use of folic acid. In the current study, clinical pharmacists should strengthen the evaluation of rational use of folic acid in the aspects of over-indication.
陶依然, 于芝颖, 黄琳, 刘刚, 赵美, 封宇飞. 门诊患者口服叶酸片超适应证用药调查分析[J]. 中国药学杂志, 2020, 55(14): 1158-1162.
TAO Yi-ran, YU Zhi-ying, HUANG Lin, LIU Gang, ZHAO Mei, FENG Yu-fei. Investigation and Analysis of Off-indication Drug Use of Folic Acid in Outpatient. Chinese Pharmaceutical Journal, 2020, 55(14): 1158-1162.
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2020, Vol. 55 
