Abstract：OBJECTIVE To investigate the protective effects of folic acid (A) with vitamin B12 (B) and vitamin B6 (C) on the learning and memory impairment of multiple cerebral infarction dementia (MID) in rats and the potential mechanisms. METHODSE The compound folic acid preparation components were used alone, in combination with each other and in combination. SD rats were randomly divided into sham operation, model group, positive control group (co-dergocrine mesylate tablets), group A, group B, group C, group AB, group AC, group BC and group ABC. The effect of folic acid, vitamin B12 and vitamin B6 on learning and memory function of MID model induced by autologous thrombus injection in rats was studied. RESULTS Compared with the model group, the escape latency of the ABC group was significantly shortened on the 5th day (P<0.05), the number of crossing platforms was significantly increased (P<0.05), and the number of crossing target quadrants was significantly increased (P<0.05). CONCLUSION Folic acid combined with vitamin B12 and vitamin B6 has synergistic effect. The mechanism of action may be through the protection of hippocampal nerve cell damage, to improve cognitive function, especially to prevent spatial memory disorders.
蔡正军, 苏小楠, 杨卓理, 韩雅慧, 易斌. 复方叶酸对认知功能低下模型的学习记忆功能影响[J]. 中国药学杂志, 2020, 55(14): 1148-1153.
CAI Zheng-jun, SU Xiao-nan, YANG Zhuo-li, HAN Ya-hui, YI Bin. Effect of Compound Folic Acid on Learning and Memory of Cognitive Impairment Model. Chinese Pharmaceutical Journal, 2020, 55(14): 1148-1153.
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2020, Vol. 55 
