Research Progress on the Relationship between Folate Deficiency and Commonmentaldisorders
CHENG Dong-mei1, WU Jiang2, DING Xin1
1. Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China; 2. Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
Abstract：Folate is a water-soluble vitamin. Deficiency of folate may not only lead to abnormal neural tube development in the embryo, but also affect brain function.This paper reviews the association of folate deficiency with depression, anxiety, obsessional disorder, schizophrenia and other psychiatric disorders, as well as the effect of folate supplementation on adjuvant therapy for psychiatric disorders.
程冬梅, 武江, 丁新. 叶酸缺乏与常见精神疾病关系研究进展[J]. 中国药学杂志, 2020, 55(14): 1143-1147.
CHENG Dong-mei, WU Jiang, DING Xin. Research Progress on the Relationship between Folate Deficiency and Commonmentaldisorders. Chinese Pharmaceutical Journal, 2020, 55(14): 1143-1147.
HERBERT V. Experimental nutritional folate deficiency in man[J]. Trans Assoc Am Phys, 1962, 75(75):307.
[2]
ALMEIDA O P, MCCAUL K, HANKEY G J, et al. Homocysteine and depression in later life[J]. Arch Gen Psychiatr, 2008, 65(11):1286-1294.
[3]
World Health Organization. Depression[EB/OL]. [2018-03-22]. http://www.who.int/mediacentre/factsheets/fs369/en/.
[4]
MORRIS M S, FAVA M, JACQUES P F, et al. Depression and folate status in the US population[J]. Psychother Psych, 2003, 72(2):80-87.
[5]
HUANG X, FAN Y, HAN X, et al. Association between serum vitamin levels and depression in US adults 20 years or older based on National Health and Nutrition Examination Survey 2005-2006 [J]. Int J Environ Res Public Health, 2018, 15(6): 1215.
[6]
BENDER A, HAGAN K E, KINGSTON N. The association of folate and depression: a Meta-analysis[J]. J Psychiatr Res, 2017, 95:9-18.
[7]
COPPEN A. Treatment of depression: time to consider folic acid and vitamin B12[J]. J Psychopharmacol, 2005, 19(1):59-65.
[8]
GOUGEON L, PAYETTE H, MORAIS J A, et al. Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging[J]. Eur J Clin Nutr, 2016, 70:380-385.
[9]
LEWIS S J, LAWLOR D A, DAVEY SMITH G, et al. The thermolabile variant of MTHFR is associated with depression in the British Women\"s Heart and Health Study and a Meta-analysis[J]. Mole Psychiatr, 2006, 11(4):352-360.
[10]
Committee on Obstetric Practice. The American College of Obstetricians and Gynecologists Committee Opinion no. 630. Screening for perinatal depression.[J]. Obstetr Gynecol, 2015, 125(5):1268-1271.
[11]
DING H, CHEN L, DI X L. Expert consensus on guidelines for the Prevention and treatment of postpartum depression disorders(Based on obstetrics and community physicians)[J]. Chin J Clin Obstet Gynecol(中国妇产科临床杂志), 2014,15(6):572-576.
[12]
LI W H, LI S L, TAN Y. Research progress of postpartum depression in China[J]. Chin J Reprod Health(中国生育健康杂志),2016, 27(1):98-100.
[13]
NICE Pathway last updated: [EB/OL] (2019-11-06). 06 November 2019:http://pathways.nice.org.uk/pathways/antenatal-and-postnatal-mental-health.
[14]
MA X H, SONG F L, KANG S L, et al. Study of the Edinburgh postnatal depression scale in the screening of postpartum depression[J]. Chin J Med(中国医刊),2017,052(002):52-56,57.
[15]
CHONG M F, WONG J X, COLEGA M, et al. Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: the GUSTO study[J]. J Psychiatr Res, 2014, 55:110-116.
[16]
JING Y, YUYAN L, LUJIA C, et al. Association between duration of folic acid supplementation during pregnancy and risk of postpartum depression[J]. Nutrients, 2017, 9(11):1206.
[17]
TRUJILLO J, VIEIRA M C, LEPSCH J, et al. A systematic review of the associations between maternal nutritional biomarkers and depression and/or anxiety during pregnancy and postpartum[J]. J Affect Disord, 2018, 232:185-203.
[18]
MISCHOULON D, RAAB M F. The role of folate in depression and dementia[J]. J Clin Psychiatr, 2007, 68(10):28-33.
[19]
PAPAKOSTAS G I, PETERSEN T, MISCHOULON D, et al. Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depression[J]. J Clin Psychiatr, 2004,65:1090-1095.
[20]
COPPEN A, BAILEY J. Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial[J]. J Affect Disord, 2000, 60:121-130.
[21]
ROBERTS E, CARTER B, YOUNG A H. Caveat emptor: folate in unipolar depressive illness, a systematic review and Meta-analysis[J]. J Psychopharmacol, 2018, 32:377-384.
[22]
BLUNDEN C H, INSKIP H M, ROBINSON S M, et al. Postpartum depressive symptoms: the B-vitamin link[J]. Ment Health Fam Med, 2012, 9:5-13.
[23]
GOUGEON L, PAYETTE H, MORAIS J A, et al. Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging[J]. Eur J Clin Nutr, 2016,70:380-385.
[24]
BEDSON E, BELL D, CARR D, et al. Folate augmentation of treatment-evaluation for depression (FolATED): randomised trial and economic evaluation[J]. Health Technol Assess, 2014, 18:Ⅶ-Ⅷ,1-159.
[25]
SARRIS J, MURPHY J, MISCHOULON D, et al. Adjunctive nutraceuticals for depression: a systematic review and Meta-analyses[J]. Am J Psychiatr, 2016,173:575-587.
[26]
TRINCADO J, CANEO C. Is augmentation with folate effective for major depressive disorder?[J]. Medwave, 2018,18(1):e7155.
[27]
SARRIS J, MURPHY J, MISCHOULON D, et al. Adjunctive nutraceuticals for depression: a systematic review and Meta-analyses[J]. Am J Psychiatr, 2016, 173:575-587.
[28]
NIERENBERG A A, MONTANA R, KINRYS G, et al. L-methylfolate for bipolar I depressive episodes: an open trial proof-of-concept registry[J]. J Affect Disord, 2017, 207:429-433.
[29]
KIEFER D. L-methylfolate for bipolar disorder[J]. Integr Med Alert, 2018, 21(1):5-6.
[30]
LI Q W, WU W Y. CLINICAL PRACTICE GUIDELINES Management of Anxiety Disorders.The Canadian Journal of Psychia [J]. J Int Psychiatr (国际精神病学杂志),2008,35(2):103-107.
[31]
ZHOU Y Y, BI Y H, LAO L M, et al. The application of generalized anxiety Scale in the screening of generalized anxiety disorder[J]. Chin J Gen Pract(中华全科医师杂志),2018,17(9):735-737
[32]
FERGUSON S A, BERRY K J, HANSEN D K, et al. Behavioral effects of prenatal folate deficiency in mice[J]. Birth Defects Res, 2005, 73(4):249-252.
[33]
ZHAO G, FORD E S, LI C, et al. Use of folic acid and vitamin supplementation among adults with depression and anxiety: a cross-sectional, population-based survey[J]. Nutr J, 2011, 10(1):102-102.
[34]
YUAN G Y, ZHANG X B, WU A Q, Research progress of three theoretical models of anxiety and depression[J]. Chin J Psychiatr(中华精神科杂志), 2001(1):55-57.
[35]
ROBBINS T W, VAGHI M M, BANCA P. Obsessive-compulsive disorder: puzzles and prospects[J]. Neuron, 2019, 102(1):27-47.
[36]
ATMACA M, TEZCAN E, KULOGLU M, et al. Serum folate and homocysteine levels in patients with obsessive-compulsive disorder [J]. Psychiatr Clin Neurosci, 2005, 59(5):616-620.
[37]
ERMAN ESNAFOLU, ELIFYAMAN. Vitamin B12, folic acid, homocysteine and vitamin D levels in children and adolescents with obsessive compulsive disorder[J]. Psychiatr Res, 2017, 254:232.
[38]
HERMESH H, WEIZMAN A, SHAHAR A, et al. Vitamin B12 and folic acid serum levels in obsessive compulsive disorder[J]. Acta Psychiatr Scandinav, 1988, 78(1):8-10.
[39]
Nuray Türksoy, Rabia Bilici, Altan Yalçner, et al. Vitamin B12, folate, and homocysteine levels in patients with obsessive-compulsive disorder[J]. Neuropsychiatr Dis Treat, 2014, 10:1671-1675.
[40]
TURAL Ü, ÇORAPÇIOLU A, BOSGELMEZS, et al. Double blind controlled study of adding folic acid to fluoxetine in the treatment of OCD[J]. Psychiatr Danub, 2019, 31(1):69-77.
[41]
ARROLL M, WILDER L, NEIL J. Nutritional interventions for the adjunctive treatment of schizophrenia: a brief review[J]. Nutr J, 2014, 13(1):91.
[42]
SUSSER E, NEUGEBAUER R, HOEK H W, et al. Schizophrenia after prenatal famine. Further evidence[J]. Arch Gen Psychiatr, 1996, 53(1):25-31.
[43]
MUNTJEWERFF J W, PUT N V D, ESKES T, et al. Homocysteine metabolism and B-vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophrenia[J]. Psychiatr Res, 2003, 121(1):1-9.
[44]
GOFF D C, BOTTIGLIERI T, ARNING E, et al. Folate, homocysteine, and negative symptoms in schizophrenia[J]. Am J Psychiatr, 2004, 161(9):1705-1708.
[45]
LERNER V, KANEVSKY M, DWOLATZKY T, et al. Vitamin B12 and folate serum levels in newly admitted psychiatric patients[J]. Clin Nutr, 2006, 25(1):60-67.
[46]
ARTHY C C, AMIN M M, EFFENDY E. Comparison of folic acid levels in schizophrenic patients and control groups[C]. IOP Conference Series Earth Environ Sci, 2018:125.
[47]
ZUGNO A I, CANEVER L, HEYLMANN A S, et al. Effect of folic acid on oxidative stress and behavioral changes in the animal model of schizophrenia induced by ketamine[J]. J Psychiatr Res, 2016,10(81):23-35.
[48]
GODFREY P S A, TOONE B K, BOTTIGLIEN T, et al. Enhancement of recovery from psychiatric illness by methylfolate[J]. The Lancet, 1990, 336(8720):953-954.
[49]
SAKUMA K, MATSUNAGA S, NOMURA I, et al. Folic acid/methylfolate for the treatment of psychopathology in schizophrenia: a systematic review and Meta-analysis[J]. Psychopharmacology, 2018,235(8):2303-2314.
[50]
ROFFMAN J L, BROHAWN D G, NITENSON A Z, et al. Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia[J]. Schizophrenia Bull, 2013, 39(2):330-338.
[51]
ROFFMAN J L, LAMBERTI J, ACHTYES E, et al. Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia[J]. JAMA Psychiatr, 2013, 70(5):481-489.
[52]
BROWN H E, ROFFMAN J L. Vitamin supplementation in the treatment of schizophrenia[J]. CNS Drugs, 2014, 28(7):611-622.
2020, Vol. 55 
